SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy
K Mardinian, JJ Adashek, GP Botta, S Kato… - Molecular cancer …, 2021 - AACR
The SWI/SNF chromatin remodeling complex, via nucleosome topology modulation,
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy
Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF
(switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene …
(switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene …
A pan-cancer analysis of SMARCA4 alterations in human cancers
L Peng, J Li, J Wu, B Xu, Z Wang, G Giamas… - Frontiers in …, 2021 - frontiersin.org
Background SMARCA4, the essential ATPase subunit of SWI/SNF chromatin remodeling
complex, regulates transcription through the control of chromatin structure and is …
complex, regulates transcription through the control of chromatin structure and is …
Recent updates in thoracic SMARCA4-deficient undifferentiated tumor
A Nambirajan, D Jain - Seminars in Diagnostic Pathology, 2021 - Elsevier
Germline inactivating mutations in SMARCA4 (SWI/SNF-related, matrix-associated, actin-
dependent regulator of chromatin, subfamily A, member 4) gene encoding for BRG1 …
dependent regulator of chromatin, subfamily A, member 4) gene encoding for BRG1 …
The i-motif as a molecular target: more than a complementary DNA secondary structure
SL Brown, S Kendrick - Pharmaceuticals, 2021 - mdpi.com
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria
Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2
characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of …
characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of …
SWI/SNF complex-deficient soft tissue neoplasms: an update
IM Schaefer, JL Hornick - Seminars in diagnostic pathology, 2021 - Elsevier
Abstract The SWItch Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex is
a large multi-subunit protein assembly that orchestrates chromatin compaction and …
a large multi-subunit protein assembly that orchestrates chromatin compaction and …
Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies
X Xu, X Pan, T Wang, J Wang, B Yang, Q He… - Acta Pharmacologica …, 2021 - nature.com
Abnormal activation of the cyclin-dependent kinases (CDKs), which result in aberrant cell
proliferation, is one of the inherent characteristics of tumor. Thus targeting the activity of …
proliferation, is one of the inherent characteristics of tumor. Thus targeting the activity of …
SWI/SNF-deficient head and neck neoplasms: An overview
With wide-spread use of next generation sequencing tools in surgical pathology, a variety of
neoplasms have been increasingly recognized to be associated with specific recurrent …
neoplasms have been increasingly recognized to be associated with specific recurrent …
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
OA Romero, A Vilarrubi, JJ Alburquerque-Bejar… - Nature …, 2021 - nature.com
Despite the genetic inactivation of SMARCA4, a core component of the SWI/SNF-complex
commonly found in cancer, there are no therapies that effectively target SMARCA4-deficient …
commonly found in cancer, there are no therapies that effectively target SMARCA4-deficient …