Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

The number of therapies for heart failure (HF) with reduced ejection fraction has nearly
doubled in the past decade. In addition, new therapies for HF caused by hypertrophic and …

Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …

The discovery of soluble GC (sGC) stimulators and sGC activators provided valuable tools to
elucidate NO–sGC signalling and opened novel pharmacological opportunities for …

Abstract When Furchgott, Murad, and Ignarro were honored with the Nobel prize for the
identification of nitric oxide (NO) in 1998, the therapeutic implications of this discovery could …

Global epidemiological studies reported a shift from maternal/infectious communicable
diseases to chronic non-communicable diseases and a major part is attributable to …

Herein we describe the discovery, mode of action, and preclinical characterization of the
soluble guanylate cyclase (sGC) activator runcaciguat. The sGC enzyme, via the formation …

Soluble guanylate cyclase (sGC) is the receptor for nitric oxide (NO) in human. It is an
important validated drug target for cardiovascular diseases. sGC can be pharmacologically …

Myeloperoxidase (MPO) is a prominent mammalian heme peroxidase and a fundamental
component of the innate immune response against microbial pathogens. In recent times …

Airway epithelium forms a physical barrier that protects the lung from the entrance of inhaled
allergens, irritants, or microorganisms. This epithelial structure is maintained by tight …