Because of the problems associated with opioids, drug discovery efforts have been
employed to develop opioids with reduced side effects using approaches such as biased …

The bidirectional relationship between depression and chronic pain is well-recognized, but
their clinical management remains challenging. Here we characterize the shared risk factors …

Psychotropic drugs are used in the treatment of psychiatric and non-psychiatric conditions.
Many patients who are on psychotropic medications may present for procedures requiring …

Objectives This randomized open‐label trial compared the efficacy and tolerability of
vortioxetine (15 mg/daily) with different antidepressants in the treatment of patients with …

Chronic neuropathic pain (CNP) is a disabling medical condition that impairs the health-
related quality-of-life of affected patients. A high prevalence of anxiety, depression, sleep …

The multimorbidity formed by sleep disturbances and pain conditions is highly prevalent and
has a significant impact in global health and in the socioeconomic system. Although different …

Abstract Purpose of Review This is a comprehensive review of the literature regarding post-
surgical cutaneous nerve entrapment, epidemiology, pathophysiology, and clinical …

Pain and depression have been assessed to co-occur in up to 80% of patients, and this
comorbidity is more debilitating and pricier for the patients as compared to either of these …

Objective. Literature shows high rates of comorbidity between fibromyalgia (FM) and mood
disorders, especially major depressive disorder (MMD), reported in more than half of the …

Aim To estimate the extent of off‐label prescribing of antidepressants in older adults and to
characterize patients with off‐label vs on‐label prescriptions of antidepressants using a …