The neuromuscular junction: roles in aging and neuromuscular disease

SR Iyer, SB Shah, RM Lovering - International journal of molecular …, 2021 - mdpi.com
The neuromuscular junction (NMJ) is a specialized synapse that bridges the motor neuron
and the skeletal muscle fiber and is crucial for conversion of electrical impulses originating …

Neuromuscular Development and Disease: Learning From in vitro and in vivo Models

Z Fralish, EM Lotz, T Chavez, A Khodabukus… - Frontiers in cell and …, 2021 - frontiersin.org
The neuromuscular junction (NMJ) is a specialized cholinergic synaptic interface between a
motor neuron and a skeletal muscle fiber that translates presynaptic electrical impulses into …

ActRIIB: ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders

J Li, M Fredericks, M Cannell, K Wang… - The Journal of …, 2021 - Am Soc Clin Investig
Patients with neuromuscular disorders suffer from a lack of treatment options for skeletal
muscle weakness and disease comorbidities. Here, we introduce as a potential therapeutic …

Therapeutic aspects of cell signaling and communication in Duchenne muscular dystrophy

A Starosta, P Konieczny - Cellular and Molecular Life Sciences, 2021 - Springer
Duchenne muscular dystrophy (DMD) is a devastating chromosome X-linked disease that
manifests predominantly in progressive skeletal muscle wasting and dysfunctions in the …

Increasing LRP4 diminishes neuromuscular deficits in a mouse model of Duchenne muscular dystrophy

T Hui, H Jing, T Zhou, P Chen, Z Liu… - Human Molecular …, 2021 - academic.oup.com
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease characterized
by progressive wasting of skeletal muscles. The neuromuscular junction (NMJ) is a synapse …

Combining chitin biological conduits with small autogenous nerves and platelet‐rich plasma for the repair of sciatic nerve defects in rats

CF Lu, B Wang, PX Zhang, S Han, W Pi… - CNS Neuroscience …, 2021 - Wiley Online Library
Aims Peripheral nerve defects are often difficult to recover from, and there is no optimal
repair method. Therefore, it is important to explore new methods of repairing peripheral …

Drebrin regulates acetylcholine receptor clustering and organization of microtubules at the postsynaptic machinery

P Alvarez-Suarez, N Nowak… - International journal of …, 2021 - mdpi.com
Proper muscle function depends on the neuromuscular junctions (NMJs), which mature
postnatally to complex “pretzel-like” structures, allowing for effective synaptic transmission …

Heterologous fibrin biopolymer associated to a single suture stitch enables the return of neuromuscular junction to its mature pattern after peripheral nerve injury

CG Pinto, APS Leite, AA Sartori, FC Tibúrcio… - Injury, 2021 - Elsevier
Denervation leads to severe atrophy of neuromuscular junction (NMJ) structure including
decrease of the expression of fundamental proteins. Up to now, conventional suture has …

Ischemic stroke-induced polyaxonal innervation at the neuromuscular junction is attenuated by robot-assisted mechanical therapy

MHH Balch, H Harris, D Chugh, S Gnyawali… - Experimental …, 2021 - Elsevier
Ischemic stroke is a leading cause of disability world-wide. Mounting evidence supports
neuromuscular pathology following stroke, yet mechanisms of dysfunction and therapeutic …

Neuromuscular junction abnormalities in mitochondrial disease: an observational cohort study

LP Braz, YS Ng, GS Gorman, AM Schaefer… - Neurology: Clinical …, 2021 - AAN Enterprises
Objective To determine the prevalence of neuromuscular junction (NMJ) abnormalities in
patients with mitochondrial disease. Methods Eighty patients with genetically proven …