[HTML][HTML] Neuroinflammation: a signature or a cause of epilepsy?

E Pracucci, V Pillai, D Lamers, R Parra… - International journal of …, 2021 - mdpi.com
Epilepsy can be both a primary pathology and a secondary effect of many neurological
conditions. Many papers show that neuroinflammation is a product of epilepsy, and that in …

[HTML][HTML] Towards a treatment for neuroinflammation in epilepsy: interleukin-1 receptor antagonist, anakinra, as a potential treatment in intractable epilepsy

G Yamanaka, Y Ishida, K Kanou, S Suzuki… - International Journal of …, 2021 - mdpi.com
Febrile Infection-Related Epilepsy Syndrome (FIRES) is a unique catastrophic epilepsy
syndrome, and the development of drug-resistant epilepsy (DRE) is inevitable. Recently …

[HTML][HTML] Saracatinib, a Src tyrosine kinase inhibitor, as a disease modifier in the rat DFP model: sex differences, Neurobehavior, gliosis, neurodegeneration, and nitro …

M Gage, M Putra, L Wachter, K Dishman, M Gard… - Antioxidants, 2021 - mdpi.com
Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure
causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective …

The role of inflammatory mediators in epilepsy: focus on developmental and epileptic encephalopathies and therapeutic implications

A Orsini, T Foiadelli, G Costagliola, A Michev… - Epilepsy Research, 2021 - Elsevier
In recent years, there has been an increasing interest in the potential involvement of
neuroinflammation in the pathogenesis of epilepsy. Specifically, the role of innate immunity …

Interleukin-1β in peripheral monocytes is associated with seizure frequency in pediatric drug-resistant epilepsy

G Yamanaka, T Takamatsu, S Morichi… - Journal of …, 2021 - Elsevier
In this study, we assessed circulating immune cells and plasma cytokine levels in 15
pediatric patients with drug-resistant epilepsy (DRE). DRE patients had a significantly higher …

An inventory of basic research in temporal lobe epilepsy

T Marissal - Revue Neurologique, 2021 - Elsevier
Temporal lobe epilepsy is a severe neurological disease, characterized by seizure
occurrence and invalidating cognitive co-morbidities, which affects up to 1% of the adults …

Towards a Treatment for Neuroinflammation in Epilepsy: Interleukin-1 Receptor Antagonist, Anakinra, as a Potential Treatment in Intractable Epilepsy

Y Ishida, K Kanou, S Suzuki… - International …, 2021 - search.proquest.com
Abstract Febrile Infection-Related Epilepsy Syndrome (FIRES) is a unique catastrophic
epilepsy syndrome, and the development of drug-resistant epilepsy (DRE) is inevitable …

Methods for the Screening of New Chemical Entities for Deciphering Neuroinflammatory and Associated Pathways in Seizures: An In Vitro Perspective

P Vyas, R Tulsawani, D Vohora - Experimental and Translational Methods …, 2021 - Springer
In the past few years, several conventional neuroinflammation-mediated epilepsy models
have been modified to correlate the same with the actual clinical pathophysiological pattern …

NLRP3 inflammasome-driven neurodegeneration and epileptiform activity in a model of epileptogenesis in organotypic slices

FJG Meda - 2021 - repositorio.ul.pt
Epilepsy is a neurological disorder characterized by periods of spontaneous and excessive
brain activity. It affects 65 million people worldwide, and despite the available therapies, 30 …

Unravelling the contribution of glial cells for the neuroinflammatory milieu of epileptic-like organotypic slices

MCP Carvalho - 2021 - repositorio.ul.pt
Epilepsy is one of the most prevalent neurological disorders that affects around 65 million
people worldwide. The term epilepsy comprises several neurological disorders …