[PDF][PDF] Detect and destroy: CRISPR-based technologies for the response against viruses
CA Freije, PC Sabeti - Cell host & microbe, 2021 - cell.com
Despite numerous viral outbreaks in the last decade, including a devastating global
pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas …
pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas …
[HTML][HTML] Off-target analysis in gene editing and applications for clinical translation of CRISPR/Cas9 in HIV-1 therapy
As genome-editing nucleases move towards broader clinical applications, the need to
define the limits of their specificity and efficiency increases. A variety of approaches for …
define the limits of their specificity and efficiency increases. A variety of approaches for …
[PDF][PDF] Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir
Small CD4-mimetic compounds (CD4mc) sensitize HIV-1-infected cells to antibody-
dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that …
dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that …
From bench side to clinic: Potential and challenges of RNA vaccines and therapeutics in infectious diseases
M Pandey, D Ojha, S Bansal, AB Rode… - Molecular Aspects of …, 2021 - Elsevier
The functional and structural versatility of Ribonucleic acids (RNAs) makes them ideal
candidates for overcoming the limitations imposed by small molecule-based drugs. Hence …
candidates for overcoming the limitations imposed by small molecule-based drugs. Hence …
[HTML][HTML] Advances in humanized mouse models to improve understanding of HIV-1 pathogenesis and immune responses
A Gillgrass, JM Wessels, JX Yang… - Frontiers in …, 2021 - frontiersin.org
Although antiretroviral therapy has transformed human immunodeficiency virus-type 1 (HIV-
1) from a deadly infection into a chronic disease, it does not clear the viral reservoir, leaving …
1) from a deadly infection into a chronic disease, it does not clear the viral reservoir, leaving …
[HTML][HTML] A short overview of CRISPR-Cas technology and its application in viral disease control
Abstract Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) together
with CRISPR-associated (Cas) proteins have catalysed a revolution in genetic engineering …
with CRISPR-associated (Cas) proteins have catalysed a revolution in genetic engineering …
[HTML][HTML] The application of CRISPR/Cas systems for antiviral therapy
HJE Baddeley, M Isalan - Frontiers in Genome Editing, 2021 - frontiersin.org
As CRISPR/Cas systems have been refined over time, there has been an effort to apply
them to real world problems, such as developing sequence-targeted antiviral therapies …
them to real world problems, such as developing sequence-targeted antiviral therapies …
HIV-1 cure strategies: why CRISPR?
AJ Atkins, AG Allen, W Dampier… - Expert opinion on …, 2021 - Taylor & Francis
Introduction Antiretroviral therapy (ART) has transformed prognoses for HIV-1-infected
individuals but requires lifelong adherence to prevent viral resurgence. Targeted elimination …
individuals but requires lifelong adherence to prevent viral resurgence. Targeted elimination …
[HTML][HTML] CRISPR-based strategies in infectious disease diagnosis and therapy
A Binnie, E Fernandes, H Almeida-Lousada… - Infection, 2021 - Springer
Purpose CRISPR gene-editing technology has the potential to transform the diagnosis and
treatment of infectious diseases, but most clinicians are unaware of its broad applicability …
treatment of infectious diseases, but most clinicians are unaware of its broad applicability …
Could gene therapy cure HIV?
Abstract The Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome
(AIDS) continues to be a major global public health issue, having claimed almost 33 million …
(AIDS) continues to be a major global public health issue, having claimed almost 33 million …