Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

A well-balanced intercellular communication between the different cells within the heart is
vital for the maintenance of cardiac homeostasis and function. Despite remarkable advances …

Hepatic ischemia reperfusion injury (IRI) occurs in liver transplantation, complex liver
resection, and hemorrhagic shock, which causes donor organ shortage and hepatic …

In the heart, connexins form gap junctions, hemichannels, and are also present within
mitochondria, with connexin 43 (Cx43) being the most prominent connexin in the ventricles …

Diabetic retinopathy (DR) is one of the main causes of vision loss in the working age
population. It is characterized by a progressive deterioration of the retinal microvasculature …

Activation of CX43 signaling protects myocardial cells from myocardial ischemia/reperfusion
(I/R) injury. However, the underlying mechanism remains unclear. MicroRNAs (miRNAs) are …

Diabetic retinopathy (DR) is one of the most common causes of vision loss and blindness
among the working-age population. High glucose (HG)-induced decrease in mitochondrial …

Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac
homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac …

Post-translational modifications based on redox reactions “switch on-off” the biological
activity of different downstream targets, modifying a myriad of processes and providing an …

Background Recent studies have shown that endothelin-1 and angiotensin II (AngII) can
increase gap junctional intercellular communication (GJIC) by activating Mitogen-activated …