Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

Summary Protein homeostasis, or" proteostasis," is indispensable for a balanced, healthy
environment within the cell. However, when natural proteostasis mechanisms are …

Of late, targeted protein degradation (TPD) has surfaced as a novel and innovative chemical
tool and therapeutic modality. By co-opting protein degradation pathways, TPD facilitates …

Conspectus One of the biggest bottlenecks in modern drug discovery efforts is in tackling the
undruggable proteome. Currently, over 85% of the proteome is still considered undruggable …

Reprogramming known medicines for a novel target with activity and selectivity over the
canonical target is challenging. By studying the binding interactions between RNA folds and …

Molecular single cell analyses provide insights into physiological and pathological
processes. Here, in a stepwise approach, we first evaluate 19 protocols for single cell small …

The most common cause of amyotrophic lateral sclerosis and frontotemporal dementia
(c9ALS/FTD) is an expanded G4C2 RNA repeat [r (G4C2) exp] in chromosome 9 open …

SARS-CoV-2 has exploded throughout the human population. To facilitate efforts to gain
insights into SARS-CoV-2 biology and to target the virus therapeutically, it is essential to …

Simple Summary Cancer onset and progression are promoted by high deregulation of the
immune system. Recently, major advances in molecular and clinical cancer immunology …

The ongoing COVID-19/Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2)
pandemic has become a significant threat to public health and has hugely impacted …