Intertwined and finely balanced: endoplasmic reticulum morphology, dynamics, function, and diseases

HT Perkins, V Allan - Cells, 2021 - mdpi.com
The endoplasmic reticulum (ER) is an organelle that is responsible for many essential
subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like …

[PDF][PDF] Multiple roles for actin in secretory and endocytic pathways

R Chakrabarti, M Lee, HN Higgs - Current Biology, 2021 - cell.com
Actin filaments play multiple roles in the secretory pathway and in endosome dynamics in
mammals, including maintenance of Golgi structure, release of membrane cargo from the …

[PDF][PDF] ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER

AV Weigel, CL Chang, G Shtengel, CS Xu, DP Hoffman… - Cell, 2021 - cell.com
Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response

Z Zhang, S Luo, GO Barbosa, M Bai, TB Kornberg… - PLoS …, 2021 - journals.plos.org
Dysregulation of collagen production and secretion contributes to aging and tissue fibrosis
of major organs. How procollagen proteins in the endoplasmic reticulum (ER) route as …

[PDF][PDF] Unscrambling exit site patterns on the endoplasmic reticulum as a quenched demixing process

K Speckner, L Stadler, M Weiss - Biophysical Journal, 2021 - cell.com
The endoplasmic reticulum (ER) is a vital organelle in mammalian cells with a complex
morphology. Consisting of sheet-like cisternae in the cell center, the peripheral ER forms a …

Positioning of endoplasmic reticulum exit sites around the Golgi depends on BicaudalD2 and Rab6 activity

O Shomron, K Hirschberg, A Burakov, R Kamentseva… - Traffic, 2021 - Wiley Online Library
The endoplasmic reticulum (ER) is involved in biogenesis, modification and transport of
secreted and membrane proteins. The ER membranes are spread throughout the cell …

Unconventional copii-mediated secretory protein trafficking continues in the absence of the sar1 gtpase

W Kasberg, P Luong, M Hanna, K Minushkin, A Tsao… - 2021 - researchsquare.com
Coat protein complex II (COPII) plays an integral role in the packaging of secretory cargoes
within membrane-enclosed transport carriers that leave the endoplasmic reticulum (ER) from …

A high throughput SEC23 functional interaction screen reveals a role for focal adhesion and extracellular matrix signalling in the regulation of COPII subunit SEC23A

J Jung, MM Khan, J Landry, A Halavatyi, P Machado… - bioRxiv, 2021 - biorxiv.org
Proteins that enter the secretory pathway are transported from their place of synthesis in the
Endoplasmic Reticulum to the Golgi complex by COPII coated carriers. The components of …

Interrelations entre les filaments de septines, les microfilaments d'actine et les microtubules: adaptations fonctionnelles en réponse aux taxanes

J Salameh - 2021 - theses.hal.science
Les septines, une famille de GTPases qui s' oligomérisent en filaments, forment un nouvel
élément du cytosquelette. Principalement alignés avec l'actine corticale et les fibres de …

[PDF][PDF] 160. 小胞体出芽部位の局在は分泌機能と関連するか?

馬場崇 - 2021 - ueharazaidan.or.jp
分泌タンパク質は小胞体内で合成されたのち, 小胞体上の特別なドメインである ER exit site
(ERES, 小胞体出芽部位) から COPII 被覆小胞に詰め込まれ, ゴルジ体を経由して細胞外 …