Multi-target drug candidates for multifactorial Alzheimer's disease: AChE and NMDAR as molecular targets
MS Uddin, A Al Mamun, MT Kabir, GM Ashraf… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is one of the most common forms of dementia among elder
people, which is a progressive neurodegenerative disease that results from a chronic loss of …
people, which is a progressive neurodegenerative disease that results from a chronic loss of …
[PDF][PDF] Association of Crocus sativus with cognitive dysfunctions and Alzheimer's disease: a systematic review
Alzheimer's disease (AD) is known as a principle basis of cognitive impairment in the elderly
population. Current available therapeutic approaches are not applicable enough for the …
population. Current available therapeutic approaches are not applicable enough for the …
Disease‐modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil
F Vasilopoulou, S Rodríguez‐Arévalo… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose The development of effective therapeutic strategies against
Alzheimer's disease (AD) remains a challenge. I2 imidazoline receptor ligands have a …
Alzheimer's disease (AD) remains a challenge. I2 imidazoline receptor ligands have a …
A “two-birds-one-stone” approach toward the design of bifunctional human immunodeficiency virus type 1 entry inhibitors targeting the CCR5 coreceptor and gp41 N …
C Wang, X Wang, H Wang, J Pu, Q Li, J Li… - Journal of Medicinal …, 2021 - ACS Publications
Previous studies have reported the stepwise nature of human immunodeficiency virus type 1
(HIV-1) entry and the pivotal role of coreceptor CCR5 and the gp41 N-terminal heptad …
(HIV-1) entry and the pivotal role of coreceptor CCR5 and the gp41 N-terminal heptad …
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo
M Kaniakova, J Korabecny, K Holubova… - Biochemical …, 2021 - Elsevier
N-methyl-D-aspartaterecepro receptor (NMDARs) are a subclass of glutamate receptors,
which play an essential role in excitatory neurotransmission, but their excessive …
which play an essential role in excitatory neurotransmission, but their excessive …
NPD1 Enhances autophagy and reduces hyperphosphorylated tau and amyloid-β 42 by inhibiting GSK3β activation in N2a/APP695swe cells
S Dai, F Zhou, J Sun, Y Li - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Background: The most prevalent kind of dementia, Alzheimer's disease (AD), is a
neurodegenerative disease. Previous research has shown that glycogen synthase kinase …
neurodegenerative disease. Previous research has shown that glycogen synthase kinase …
[PDF][PDF] Targeting Alzheimer's disease through Pharmacoinformatics: New Challenges in Drug Design. Alzheimer's Disease and Treatment
D Ramírez, L Arrue, M Reyes-Parada - 2021 - meddocsonline.org
Pharmacoinformatics emerged from the use of integrative methods from biology, chemistry,
pharmacology and informatics, thereby facilitating the design of new strategies to identify …
pharmacology and informatics, thereby facilitating the design of new strategies to identify …