Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Although low risk localised prostate cancer has an excellent prognosis owing to effective
treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …

Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and
reduces energy production, is known to be effective against cancer types that depend on …

Photodynamic therapy (PDT), a non-invasive therapeutic modality, has received increasing
attention owing to its high selectivity and limited side effects. Although significant clinical …

The transcriptomic classification of glioblastoma (GBM) has failed to predict survival and
therapeutic vulnerabilities. A computational approach for unbiased identification of core …

Emerging evidence has shown that open reading frames inside long noncoding RNAs
(lncRNAs) could encode micropeptides. However, their roles in cellular energy metabolism …

Chemotherapy remains the standard of care for most cancers worldwide, however
development of chemoresistance due to the presence of the drug-effluxing ATP binding …

Oxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA
from pretreatment biopsies from patients with triple-negative breast cancer (TNBC) who …

Therapy resistance represents a major clinical challenge in acute myeloid leukemia (AML).
Here we define a 'MitoScore'signature, which identifies high mitochondrial oxidative …

Cancer cells face various metabolic challenges during tumor progression, including growth
in the nutrient-altered and oxygen-deficient microenvironment of the primary site …