The accumulation and molecular effects of trimethylamine N-oxide on metabolic tissues: It's not all bad

ES Krueger, TS Lloyd, JS Tessem - Nutrients, 2021 - mdpi.com
Since elevated serum levels of trimethylamine N-oxide (TMAO) were first associated with
increased risk of cardiovascular disease (CVD), TMAO research among chronic diseases …

Therapeutic drug monitoring of second-and third-generation antipsychotic drugs—influence of smoking behavior and inflammation on pharmacokinetics

N Moschny, G Hefner, R Grohmann, G Eckermann… - Pharmaceuticals, 2021 - mdpi.com
Both inflammation and smoking can influence a drug's pharmacokinetic properties, ie, its
liberation, absorption, distribution, metabolism, and elimination. Depending on, eg …

Sugar fructose triggers gut dysbiosis and metabolic inflammation with cardiac arrhythmogenesis

WL Cheng, SJ Li, TI Lee, TW Lee, CC Chung, YH Kao… - Biomedicines, 2021 - mdpi.com
Fructose is a main dietary sugar involved in the excess sugar intake-mediated progression
of cardiovascular diseases and cardiac arrhythmias. Chronic intake of fructose has been the …

[HTML][HTML] Multi-omics: Opportunities for research on mechanism of type 2 diabetes mellitus

S Wang, H Yong, XD He - World journal of diabetes, 2021 - ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) is a burdensome global disease. In-depth understanding of
its mechanism will help to optimize diagnosis and treatment, which reduces the burden …

[HTML][HTML] Holistic perspective of the role of gut microbes in diabetes mellitus and its management

K Alagiakrishnan, T Halverson - World Journal of Diabetes, 2021 - ncbi.nlm.nih.gov
The gut microbiota (GM) plays a role in the development and progression of type 1 and type
2 diabetes mellitus (DM) and its complications. Gut dysbiosis contributes to the …

Probiotics supplementation and cardiometabolic risk factors: A new insight into recent advances, potential mechanisms, and clinical implications

A Salari, M Mahdavi-Roshan, J Kheirkhah, Z Ghorbani - PharmaNutrition, 2021 - Elsevier
Background Subjects who have cardiovascular diseases (CVDs) share a variety of common
characteristic including increased blood pressure (BP), disrupted glycemic control, and …

Vaccarin enhances intestinal barrier function in type 2 diabetic mice

J Sun, X Yu, B Hou, M Ai, M Qi, X Ma, M Cai… - European Journal of …, 2021 - Elsevier
Aims Hyperglycemia and insulin resistance drive intestinal barrier dysfunction in type 2
diabetes (T2DM). Vaccarin, the main active component in the semen of traditional Chinese …

Effects of microbiota-driven therapy on circulating trimethylamine-N-oxide metabolism: A Systematic review and meta-analysis

L Miao, J Du, Z Chen, D Shi, H Qu - Frontiers in Cardiovascular …, 2021 - frontiersin.org
Aim: This study was designed to systematically evaluate the effects of microbiota-driven
therapy on decreasing TMAO and its related metabolites. Methods and Results: PubMed …

The influence of gut microbiota on the cardiovascular system under conditions of obesity and chronic stress

P Dubinski, K Czarzasta… - Current Hypertension …, 2021 - Springer
Abstract Purpose of Review Based on the available data, it can be assumed that microbiota
is an integral part of the human body. The most heavily colonized area of the human body is …

El impacto de la microbiota en la enfermedad cardiovascular

MÁ Vega, MVC Badilla, LMQ Mora - Revista Médica Sinergia, 2021 - dialnet.unirioja.es
El término “microbiota” se refiere al ecosistema de microorganismos que coloniza el tracto
gastrointestinal. Sus funciones principales son la nutrición, metabolismo, defensa y función …