After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

Trophoblast organoids derived from placental villi provide a 3D model system of human
placental development, but access to first-trimester tissues is limited. Here, we report that …

Abstract The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in
early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has …

The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …

In primates, the amnion emerges through cavitation of the epiblast during implantation,
whereas in other species it does so later at gastrulation by the folding of the ectoderm. How …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …

In human embryos, major zygotic genome activation (ZGA) initiates at the eight-cell (8C)
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …

Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad
prospects for human therapeutic model development and livestock breeding. Despite …

The recent derivation of human trophoblast stem cells (hTSCs) provides a scalable in vitro
model system of human placental development, but the molecular regulators of hTSC …