The genetic basis for adult onset glaucoma: recent advances and future directions

Z Wang, JL Wiggs, T Aung, AP Khawaja… - Progress in Retinal and …, 2022 - Elsevier
Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …

Brain-derived neurotrophic factor-mediated neuroprotection in glaucoma: a review of current state of the art

L Lambuk, MA Mohd Lazaldin, S Ahmad… - Frontiers in …, 2022 - frontiersin.org
Retinal ganglion cells (RGCs) are neurons of the visual system that are responsible for
transmitting signals from the retina to the brain via the optic nerve. Glaucoma is an optic …

Postoperative complications in the primary tube versus trabeculectomy study during 5 years of follow-up

SJ Gedde, WJ Feuer, KS Lim, K Barton, S Goyal… - Ophthalmology, 2022 - Elsevier
Purpose To describe postoperative complications encountered in the Primary Tube Versus
Trabeculectomy (PTVT) Study during 5 years of follow-up. Design Multicenter randomized …

Blood pressure and glaucomatous progression in a large clinical population

AA Jammal, SI Berchuck, EB Mariottoni, AP Tanna… - Ophthalmology, 2022 - Elsevier
Purpose To investigate the effect of systemic arterial blood pressure (BP) on rates of
progressive structural damage over time in glaucoma. Design Retrospective cohort study …

Treatment outcomes in the primary tube versus trabeculectomy study after 5 years of follow-up

SJ Gedde, WJ Feuer, KS Lim, K Barton, S Goyal… - Ophthalmology, 2022 - Elsevier
Purpose To report 5-year treatment outcomes in the Primary Tube Versus Trabeculectomy
(PTVT) Study. Design Multicenter randomized clinical trial. Participants A total of 242 eyes of …

Finite element modeling of effects of tissue property variation on human optic nerve tethering during adduction

J Park, A Shin, JL Demer - Scientific reports, 2022 - nature.com
Tractional tethering by the optic nerve (ON) on the eye as it rotates towards the midline in
adduction is a significant ocular mechanical load and has been suggested as a cause of ON …

Apparatus, systems and methods for measuring flow and pressure within a vessel

GJ Tearney, M Suter, BE Bouma, FA Jaffer - US Patent 11,490,826, 2022 - Google Patents
Exemplary embodiments of apparatus, system and method can be provided to measure a
flow of fluid within an anatomical structure. For example, it is possible to use at least one first …

Role of decorin in the lens and ocular diseases

E Kubo, S Shibata, T Shibata, H Sasaki, DP Singh - Cells, 2022 - mdpi.com
Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is
involved in various biological functions and many signaling networks, interacting with extra …

Prospective 12-month outcomes of combined iStent inject implantation and phacoemulsification in Asian eyes with normal tension glaucoma

BCH Ang, W Chiew, VCH Yip, CH Chua, WS Han… - Eye and Vision, 2022 - Springer
Background Glaucoma is the leading cause of irreversible blindness. Normal tension
glaucoma (NTG) is a subset of open-angle glaucoma, demonstrating glaucomatous optic …

Neuroprotection in glaucoma: basic aspects and clinical relevance

CY Kuo, CJL Liu - Journal of Personalized Medicine, 2022 - mdpi.com
Glaucoma is a neurodegenerative disease that affects primarily the retinal ganglion cells
(RGCs). Increased intraocular pressure (IOP) is one of the major risk factors for glaucoma …