During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

Myocardial infarction (MI) represents one of the most prevalent cardiovascular diseases,
with a highly relevant and impactful role in public health. Despite the therapeutic advances …

Passive stiffness of the heart is determined largely by extracellular matrix and titin, which
functions as a molecular spring within sarcomeres. Titin stiffening is associated with the …

Reactivation of fetal-specific genes and isoforms occurs during heart failure. However, the
underlying molecular mechanisms and the extent to which the fetal program switch occurs …

One of the obstacles in studying the pathogenesis of hypertrophic cardiomyopathy (HCM) is
the poor availability of myocardial tissue samples at the early stages of disease …

Background: Mutations in genes encoding sarcomeric proteins lead to failures in sarcomere
assembly, the building blocks of contracting muscles, resulting in cardiomyopathies that are …

The quest for novel methods to mature human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) for cardiac regeneration, modelling and drug testing has …

Titin, as the main protein responsible for the passive stiffness of the sarcomere, plays a key
role in diastolic function and is a determinant factor in the etiology of heart disease. Titin …

Cellular mRNA-binding proteins (mRBPs) are major posttranscriptional regulators of gene
expression. Although many posttranslational modification sites in mRBPs have been …

Background: Altered kinase localization is gaining appreciation as a mechanism of
cardiovascular disease. Previous work suggests GSK-3β (glycogen synthase kinase 3β) …