Neoadjuvant B-RAF and MEK inhibitor targeted therapy for adult papillary craniopharyngiomas: a new treatment paradigm

F Calvanese, T Jacquesson, R Manet… - Frontiers in …, 2022 - frontiersin.org
Background Surgical and clinical management of craniopharyngiomas is associated with
high long-term morbidity especially in the case of hypothalamic involvement. Improvements …

The challenging management of craniopharyngiomas in adults: time for a reappraisal?

T Cuny, M Buchfelder, H Dufour, A Grossman… - Cancers, 2022 - mdpi.com
Simple Summary Craniopharyngiomas (CPs) currently represent one of the most
challenging diseases to deal with in the group of skull base tumors. Due to their location …

Molecular matched targeted therapies for primary brain tumors—a single center retrospective analysis

AL Luger, S König, PF Samp, H Urban, I Divé… - Journal of neuro …, 2022 - Springer
Purpose Molecular diagnostics including next generation gene sequencing are increasingly
used to determine options for individualized therapies in brain tumor patients. We aimed to …

Targeted therapies in the medical management of craniopharyngioma

P Iglesias - Pituitary, 2022 - Springer
Craniopharyngioma (CP) is an intracranial benign tumor that behaves aggressively due to
its location, infiltration of the surrounding nervous tissue and high capacity for recurrence …

Targeted therapy in the management of modern craniopharyngiomas

M Reyes, M Taghvaei, S Yu, A Sathe, S Collopy… - 2022 - jdc.jefferson.edu
Background: The proximity of craniopharyngiomas (CPs) to critical neurovascular structures
can lead to a host of neurologic and endocrine complications that lead to difficulty with …

Case report and literature review of BRAF‐V600 inhibitors for treatment of papillary craniopharyngiomas: A potential treatment paradigm shift.

PE Nussbaum, LA Nussbaum… - Journal of Clinical …, 2022 - search.ebscohost.com
What is known and objective: The BRAF‐V600E genetic mutation offers a potential targeted
therapy for the treatment of papillary craniopharyngiomas. Case summary: A 35‐year‐old …

Diagnosis and management of pediatric papillary craniopharyngiomas

C Zhao, Z Zhou, Y Zhang, X Qi, X Wang, D Lin, H Liu… - World Neurosurgery, 2022 - Elsevier
Objective Papillary craniopharyngioma (PCP) was previously believed to occur only in
adults. Sporadic pediatric PCP (PPCP) confirmed by detection of BRAF V600E mutation has …

[HTML][HTML] Dramatic Therapeutic Response to Dabrafenib Plus Trametinib in BRAF V600E Mutated Papillary Craniopharyngiomas: A Case Report and Literature Review

M Fasano, CM Della Corte, M Caterino… - Frontiers in …, 2022 - frontiersin.org
Background Craniopharyngioma is a rare intracranial tumor, with a high morbidity rate due
to its common refractiveness to conventional treatments. BRAF V600E mutation has recently …

[HTML][HTML] Craniopharyngiomas

K Lithgow, R Hamblin, U Pohl, N Karavitaki - Endotext [Internet], 2022 - ncbi.nlm.nih.gov
Craniopharyngiomas are rare intracranial tumors that mainly arise in the sellar/parasellar
(particularly suprasellar) region. They present in both children and adults with a wide range …

[HTML][HTML] 颅内肿瘤的靶向药物治疗

瀚王, 跃龙王, 志勇刘, 建国徐 - Journal of Sichuan University …, 2022 - ncbi.nlm.nih.gov
颅内肿瘤严重影响了人类的身心健康, 由于肿瘤的性质与生长部位的不同,
因此对颅内肿瘤患者进行个体化、 特异性的治疗已成为当下研究的热点 …