Glucocorticoids

IM Adcock, S Mumby - Encyclopedia of Molecular Pharmacology, 2022 - Springer
Definition γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the
central nervous system. Structures involved in releasing and binding GABA as a …

Corticosteroid resistance in asthma: Cellular and molecular mechanisms

G Caramori, F Nucera, S Mumby, FL Bello… - Molecular aspects of …, 2022 - Elsevier
Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …

TH17 cells and corticosteroid insensitivity in severe asthma

Y Xie, PW Abel, TB Casale, Y Tu - Journal of Allergy and Clinical …, 2022 - Elsevier
Asthma is classically described as having either a type 2 (T2) eosinophilic phenotype or a
non-T2 neutrophilic phenotype. T2 asthma usually responds to classical bronchodilation …

Intranasal curcumin and sodium butyrate modulates airway inflammation and fibrosis via HDAC inhibition in allergic asthma

R Islam, D Dash, R Singh - Cytokine, 2022 - Elsevier
Asthma being an inflammatory disease of the airways lead to structural alterations in lungs
which often results in the severity of the disease. Curcumin, diferuloylmethane, is well known …

[HTML][HTML] Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression

H Butz, A Patócs - Cancer and Metastasis Reviews, 2022 - Springer
Abstract Glucocorticoids (GCs), mostly dexamethasone (dex), are routinely administered as
adjuvant therapy to manage side effects in breast cancer. However, recently, it has been …

Recent advances in the immunopathogenesis of severe asthma

S Al Heialy, RK Ramakrishnan, Q Hamid - Journal of Allergy and Clinical …, 2022 - Elsevier
Severe asthma is a heterogeneous disease encompassing different phenotypes and
endotypes. Although patients with severe asthma constitute a small proportion of the total …

[HTML][HTML] Long-acting acid-sensitive ketal-linked dexamethasone microcrystals for treating experimental autoimmune uveitis

M Cai, Z Xu, X Zhou, L Li, X Hua, S Guo, X Yuan - APL bioengineering, 2022 - pubs.aip.org
Corticosteroids have for some time been used as first-line drugs for the topical treatment of
noninfectious uveitis, but poor ocular bioavailability and the rapid clearance of eye drops …

Synergistic effect of roflumilast with dexamethasone in a neutrophilic asthma mouse model

CK Park, TJ An, JH Kim, CK Rhee… - Clinical and …, 2022 - Wiley Online Library
Asthma is a chronic airway inflammatory disease with heterogeneous features. Most cases
of asthma are steroid sensitive, but 5%‐10% are unresponsive to steroids, leading to …

Asma: Introducción, epidemiología y conceptos

S Payaslian - REVISTA ARGENTINA DE MEDICINA, 2022 - revistasam.com.ar
El asma es una enfermedad heterogénea caracterizada por una inflamación crónica de las
vías aéreas que afecta a todos los grupos etarios. Con una prevalencia global del 4, 3%, y …

[PDF][PDF] Review of Skin Problems Caused by Stress

H Chen, T Zhang, X Xu, S Wan, Y Wang - J. Clin. Med. Res, 2022 - en.front-sci.com
Long-term exposure to social and biological/physical stressful events produces stress
responses. The hypothalamic-pituitary-adrenal (HPA) axis is one of the main …