Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells
The degeneration of nigral (A9) dopaminergic (DA) neurons causes motor symptoms in
Parkinson's disease (PD). We use small-molecule compounds to direct the differentiation of …
Parkinson's disease (PD). We use small-molecule compounds to direct the differentiation of …
Interneuronal network model of theta-nested fast oscillations predicts differential effects of heterogeneity, gap junctions and short term depression for hyperpolarizing …
G Via, R Baravalle, FR Fernandez… - PLOS Computational …, 2022 - journals.plos.org
Theta and gamma oscillations in the hippocampus have been hypothesized to play a role in
the encoding and retrieval of memories. Recently, it was shown that an intrinsic fast gamma …
the encoding and retrieval of memories. Recently, it was shown that an intrinsic fast gamma …
Protective effect of curcumin against rotenone-induced substantia nigra pars compacta neuronal dysfunction
LV Darbinyan, KV Simonyan… - Metabolic Brain …, 2022 - Springer
Rotenone is involved in the degeneration of dopaminergic neurons, and curcumin may
prevent or effectively slow the progression of Parkinson's disease (PD). Previous research …
prevent or effectively slow the progression of Parkinson's disease (PD). Previous research …
The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability
RFO Pena, HG Rotstein - Biological cybernetics, 2022 - Springer
We systematically investigate the response of neurons to oscillatory currents and synaptic-
like inputs and we extend our investigation to non-structured synaptic-like spiking inputs with …
like inputs and we extend our investigation to non-structured synaptic-like spiking inputs with …
Stochastic model in neural network-an application in pacemaker GABAergic neurons
K Guimarães, A Duarte - 2022 - researchsquare.com
In this paper we present a numerical study of a mathematical model that describes the
continuous temporal evolution of membrane potentials in a GABAergic neuronal network …
continuous temporal evolution of membrane potentials in a GABAergic neuronal network …