Following introduction of the monoamine oxidase type B inhibitor selegiline for the treatment
of Parkinson's disease (PD), discovery of the action mechanism of Alzheimer's disease …

The immune system is generally known to be the primary defense mechanism against
pathogens. Any pathological conditions are reflected in anomalies in the immune system …

Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Dopamine (DA) is a major monoamine neurotransmitter in the brain and has essential roles
in higher functions of the brain. Malfunctions of dopaminergic signaling have been …

Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

The hippocampus is essential for different forms of declarative memory, including social
memory, the ability to recognize and remember a conspecific. Although recent studies …

Recent advances in genomics have revealed a wide spectrum of genetic variants
associated with neurodevelopmental disorders at an unprecedented scale. An increasing …

Advances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing
unprecedented in vitro access to some of the molecular, cellular and developmental …

Protein S-palmitoylation is a reversible post-translational lipid modification that plays a
critical role in neuronal development and plasticity, while dysregulated S-palmitoylation …

Area CA2 is a critical region for diverse hippocampal functions including social recognition
memory. This region has unique properties and connectivity. Notably, intra-hippocampal …