T cell dysregulation in SLE

K Tenbrock, T Rauen - Clinical Immunology, 2022 - Elsevier
T helper cells aid B cells with the production of antibodies and thus play a central role in
disease development of systemic lupus erythematosus (SLE). Numerous T helper cell …

YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

Tumor temperature: friend or foe of virus-based cancer immunotherapy

JP Knapp, JE Kakish, BW Bridle, DJ Speicher - Biomedicines, 2022 - mdpi.com
The temperature of a solid tumor is often dissimilar to baseline body temperature and,
compared to healthy tissues, may be elevated, reduced, or a mix of both. The temperature of …

Role of YB-1 protein in inflammation

EY Rybalkina, NI Moiseeva - Biochemistry (Moscow), 2022 - Springer
This review discusses the role of the multifunctional DNA/RNA-binding protein YB-1 in
inflammation. YB-1 performs multiple functions in the cell depending on its location: it acts as …

Diverse regulation of YB-1 and YB-3 abundance in mammals

IA Eliseeva, EM Sogorina, EA Smolin… - Biochemistry …, 2022 - Springer
Abstract YB proteins are DNA/RNA binding proteins, members of the family of proteins with
cold shock domain. Role of YB proteins in the life of cells, tissues, and whole organisms is …

RNA methylation in immune cells

Y Chen, MH Oh, R Flavell, HB Li - Advances in Immunology, 2022 - Elsevier
The discovery of more than 170 types of RNA modifications has enabled the evolution of the
RNA “vocabulary” and given rise to the new area of “epitranscriptome”(Nombela, Miguel …

An old friend with a new face: YB-1 and its role in healthy pregnancy and pregnancy-associated complications

F Fischer, A Schumacher, N Meyer, B Fink… - Frontiers in Cell and …, 2022 - frontiersin.org
By promoting tissue invasion, cell growth and angiogenesis, the Y-box binding protein (YB-
1) became famous as multifunctional oncoprotein. However, this designation is telling only …

[HTML][HTML] Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer

K Yamada, K Yoshida - World Journal of Gastroenterology, 2022 - ncbi.nlm.nih.gov
Protein kinase Cδ (PKCδ) is a member of the PKC family, and its implications have been
reported in various biological and cancerous processes, including cell proliferation, cell …

Adjuvant effects of multifunctional transcription factor and BCG target YB-1: exogenous YB-1 enhances specific antibody production in vivo and protects mice against …

AO Shepelyakovskaya, L Alekseeva… - BioRxiv, 2022 - biorxiv.org
There is growing interest in the beneficial effects of immune system boosting through the
administration of adjuvants, not only in acute infections such as COVID but also in chronic …

Role of YB-1 and NF-κB in TNFR signaling pathways: deciding cell survival or death

A Shah - 2022 - repo.bibliothek.uni-halle.de
Y-box binding protein-1 (YB-1) belongs to the family of cold shock proteins that are
characterized by an evolutionary and structurally conserved cold shock domain. The cold …