Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Fluorophores with aggregation-induced emission (AIE) are characterized by many
advantageous features for biomedical applications, including excellent photostability and …

Lipids are key macromolecules that perform a multitude of biological functions ranging from
maintaining structural integrity of membranes, energy storage, to signaling molecules …

Lacking a self-contained metabolism network, viruses have evolved multiple mechanisms
for rewiring the metabolic system of their host to hijack the host's metabolic resources for …

Apolipoprotein E (APOE) is a component of lipoprotein particles that function in the
homeostasis of cholesterol and other lipids. Although APOE is genetically associated with …

Autophagy is an evolutionarily conserved cellular process in which macromolecules
undergo lysosomal degradation. It fulfills essential roles in quality controlling cellular …

Cellular senescence plays a causal role in ageing and, in mice, depletion of p16INK4a-
expressing senescent cells delays ageing-associated disorders,. Adenosine deaminases …

Aging in humans is intricately linked with alterations in circadian rhythms concomitant with
physiological decline and stem cell exhaustion. However, whether the circadian machinery …

Accumulation of senescent cells affects organismal aging and the prevalence of age-
associated disease. Emerging evidence suggests that activation of autophagy protects …