Single-cell sequencing reveals an intrinsic heterogeneity of the preovulatory follicular microenvironment

H Wu, R Zhu, B Zheng, G Liao, F Wang, J Ding, H Li… - Biomolecules, 2022 - mdpi.com
The follicular microenvironment, including intra-follicular granulosa cells (GCs), is
responsible for oocyte maturation and subsequent ovulation. However, the functions of GCs …

Compromised cumulus-oocyte complex matrix organization and expansion in women with PCOS

K Patil, G Shinde, I Hinduja, S Mukherjee - Reproductive Sciences, 2022 - Springer
The cumulus-oocyte complex (COC) matrix plays a critical role in the ovulation and
fertilization process and a major predictor of oocyte quality. Proteomics studies of follicular …

Intraovarian, isoform-specific transcriptional roles of progesterone receptor in ovulation

KM Smith, DT Dinh, LK Akison, M Nicholls, KR Dunning… - Cells, 2022 - mdpi.com
Progesterone receptor (PGR) activity is obligatory for mammalian ovulation; however, there
is no established direct functional pathway explaining how progesterone receptor …

Activin A promotes hyaluronan production and upregulates versican expression in human granulosa cells

S Tian, H Zhang, HM Chang, C Klausen… - Biology of …, 2022 - academic.oup.com
Hyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan
synthase 2 is the major enzyme for the synthesis of hyaluronan in humans. Versican cross …

The investigation of diverse physiological and therapeutic impact of cellular-based products derived from human cumulus cells

D Burukçu, S Yilmaz, O Alagöz… - Turkish Journal of …, 2022 - journals.tubitak.gov.tr
Particular somatic cells, namely cumulus cells (CCs) that support the oocyte maturation,
fertility, and viability by providing the nutrients and energy to the oocyte envelop the …

Contrasting effects of the Toll-like receptor 4 in determining ovarian follicle endowment and fertility in female adult mice

JP Gonçalves, BA Magalhães, PHA Campos-Junior - Zygote, 2022 - cambridge.org
Toll-like receptor 4 (TLR4) is best known for its role in bacteria-produced lipopolysaccharide
recognition. Regarding female reproduction, TLR4 is expressed by murine cumulus cells …

Isolation and purification of versican and analysis of versican proteolysis

SJ Foulcer, AJ Day, SS Apte - Glycosaminoglycans: Methods and …, 2022 - Springer
Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes
with the glycosaminoglycan hyaluronan (HA). As a consequence of HA binding to its …

Élucidation des rôles de YAP1 et TAZ dans l'ovaire chez la souris

P Godin - 2022 - papyrus.bib.umontreal.ca
L'ovaire est un organe indispensable à la fonction reproductive, car il permet la production,
la maturation et la libération de la cellule germinale femelle, l'ovocyte. Malgré son rôle …

How O-Fucosylation Stabilizes Thrombospondin Type 1 Repeats and Its Function of Quality Control in the Secretory Pathway

SJ Berardinelli - 2022 - search.proquest.com
O-fucosylation of Thrombospondin Type 1 Repeats (TSRs) is rare but essential protein
modification that occurs on a number of secreted extracellular matrix proteins. O-fucosylation …