[HTML][HTML] Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex

ZI Laszlo, N Hindley, A Sanchez Avila, RA Kline… - Acta neuropathologica …, 2022 - Springer
Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor
in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the …

[HTML][HTML] The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration

A Perry, LE Hughes, N Adams, M Naessens… - Translational …, 2022 - nature.com
There is a pressing need to accelerate therapeutic strategies against the syndromes caused
by frontotemporal lobar degeneration, including symptomatic treatments. One approach is …