Interactions of small molecules with DNA junctions
The four natural DNA bases (A, T, G and C) associate in base pairs (A= T and G≡ C),
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …
[HTML][HTML] Junctions in DNA: underexplored targets for therapeutic intervention
E Ivens, MMD Cominetti, M Searcey - Bioorganic & Medicinal Chemistry, 2022 - Elsevier
DNA has been a key target for cancer therapy, with a range of compounds able to bind and
either impair its processing or induce damage. Targeting DNA with small molecules in a truly …
either impair its processing or induce damage. Targeting DNA with small molecules in a truly …
Dinuclear nickel (ii) supramolecular helicates down-regulate gene expression in human cells by stabilizing DNA G-quadruplexes formed in the promoter regions
J Malina, H Kostrhunova, V Brabec - Inorganic Chemistry Frontiers, 2022 - pubs.rsc.org
We investigated the interaction of the M-and P-enantiomers of the dinuclear nickel (II)
tetracationic supramolecular helicate ([Ni2L3] 4+, L= C25H20N4) with a series of four DNA …
tetracationic supramolecular helicate ([Ni2L3] 4+, L= C25H20N4) with a series of four DNA …
Gaining Insights on the Interactions of a Class of Decorated (2‐([2, 2′‐Bipyridin]‐6‐yl) phenyl) platinum Compounds with c‐Myc Oncogene Promoter G‐Quadruplex …
L Savva, M Fossépré, O Keramidas… - … A European Journal, 2022 - Wiley Online Library
Organometallic molecules offer some of the most promising scaffolds for interaction with G‐
quadruplex nucleic acids. We report the efficient synthesis of a family of organoplatinum (II) …
quadruplex nucleic acids. We report the efficient synthesis of a family of organoplatinum (II) …
Revealing the specific interactions between G-quadruplexes and ligands by surface-enhanced Raman spectroscopy
Y Bao, X Zhang, X Xiang, Y Zhang, X Guo - International Journal of …, 2022 - Elsevier
Abstract G-quadruplexes (G4s) regulate a variety of physiological functions related to
diseases and life elongation. Therefore, G4 binding ligands, such as potential drugs in gene …
diseases and life elongation. Therefore, G4 binding ligands, such as potential drugs in gene …
Insight into achirality and chirality effects in interactions of an racemic ruthenium (II) polypyridyl complex and its Δ-and Λ-enantiomers with an RNA triplex
L Tan, H Wang, X Liu - International Journal of Biological Macromolecules, 2022 - Elsevier
RNA triplexes have a variety of potential applications in molecular biology, diagnostics and
therapeutics, while low stabilization of the third strand hinders their practical utilities under …
therapeutics, while low stabilization of the third strand hinders their practical utilities under …
[PDF][PDF] Retracted: g-quadruplex structural transition driven by a platinum compound
W Liu, BC Zhu, LY Liu, XY Xia… - Nucleic Acids Research, 2022 - academic.oup.com
Abstract G-quadruplex (G4) transitions play integral roles in regulating biological functions
and can be modified by ligands. However, little is known about G4 transitions. Herein, we …
and can be modified by ligands. However, little is known about G4 transitions. Herein, we …