[HTML][HTML] Racial differences in prostate cancer characteristics and cancer-specific mortality: an overview

N Hinata, M Fujisawa - The world journal of men's health, 2022 - ncbi.nlm.nih.gov
Racial differences of prostate cancer incidence and mortality among Asian, Black, and
Caucasian men have been known, however, comprehensive update of this topic is not yet …

French AFU Cancer Committee Guidelines-Update 2022-2024: prostate cancer-Diagnosis and management of localised disease

G Ploussard, G Fiard, E Barret, L Brureau… - Progrès en Urologie, 2022 - Elsevier
Objective The objective of the French Urology Association Cancer Committee is to propose
an update of the recommendations for the diagnosis and management of prostate cancer …

[HTML][HTML] African-specific molecular taxonomy of prostate cancer

W Jaratlerdsiri, J Jiang, T Gong, SM Patrick, C Willet… - Nature, 2022 - nature.com
Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a
significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than …

A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma

M Seviiri, MH Law, JS Ong, P Gharahkhani… - Nature …, 2022 - nature.com
Basal cell carcinoma and squamous cell carcinoma are the most common skin cancers, and
have genetic overlap with melanoma, pigmentation traits, autoimmune diseases, and blood …

Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

MS Kim, D Naidoo, U Hazra, MH Quiver, WC Chen… - Genome biology, 2022 - Springer
Background Genome-wide association studies do not always replicate well across
populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher …

Polygenic risk for prostate cancer: decreasing relative risk with age but little impact on absolute risk

DJ Schaid, JP Sinnwell, A Batzler… - The American Journal of …, 2022 - cell.com
Polygenic risk scores (PRSs) for a variety of diseases have recently been shown to have
relative risks that depend on age, and genetic relative risks decrease with increasing age. A …

Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study

BL Hayes, T Robinson, S Kar, KS Ruth, KK Tsilidis… - PLoS …, 2022 - journals.plos.org
Morning-preference chronotype has been found to be protective against breast and prostate
cancer. Sex hormones have been implicated in relation to chronotype and the development …

Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality

R Pidsley, D Lam, W Qu, TJ Peters… - Clinical and …, 2022 - Wiley Online Library
Background Prostate cancer is a clinically heterogeneous disease with a subset of patients
rapidly progressing to lethal‐metastatic prostate cancer. Current clinicopathological …

Inherited risk assessment and its clinical utility for predicting prostate cancer from diagnostic prostate biopsies

J Xu, WK Resurreccion, Z Shi, J Wei… - Prostate Cancer and …, 2022 - nature.com
Background Many studies on prostate cancer (PCa) germline variants have been published
in the last 15 years. This review critically assesses their clinical validity and explores their …

Prostate Cancer transcriptomic regulation by the interplay of germline risk alleles, somatic mutations, and 3D genomic architecture

J Yuan, KE Houlahan, SG Ramanand, S Lee, GH Baek… - Cancer discovery, 2022 - AACR
Prostate cancer is one of the most heritable human cancers. Genome-wide association
studies have identified at least 185 prostate cancer germline risk alleles, most noncoding …