The pathogenesis of cardiovascular disease (CVD) is complex and multifactorial, and
inflammation plays a central role. Inflammasomes are multimeric protein complexes that are …

Abstract Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that recognises the double-
strand DNA. AIM2 inflammasome is a protein platform in the cell that initiates innate immune …

The NKCC1 ion transporter contributes to the pathophysiology of common neurological
disorders, but its function in microglia, the main inflammatory cells of the brain, has remained …

Background Traumatic brain injury (TBI) triggers a set of complex inflammation that results in
secondary injury. Parthenolide (PTN) is a sesquiterpene lactone extracted from the herb …

Parkinson's disease (PD) is one of the most common neurodegenerative diseases in which
neuroinflammation plays pivotal roles. An important mechanism of neuroinflammation is the …

Our previous research demonstrated that NOD-like receptor family CARD domain-
containing protein 4 (NLRC4) inflammasome was overexpressed in renal tissues of patients …

Inflammation mediated by the innate immune system is a physiopathological response to
diverse detrimental circumstances such as microbe infections or tissular damage. The …

Gut bacteria consists of 150 times more genes than humans that are vital for health. Several
studies revealed that gut bacteria are associated with disease status and influence human …

The NAIP/NLRC4 inflammasome is classically associated with the detection of bacterial
invasion to the cytosol. However, recent studies have demonstrated that NAIP/NLRC4 is …

Inflammasomes are known to contribute to brain damage after acute ischemic stroke (AIS).
TAK1 is predominantly expressed in microglial cells and can regulate the NLRP3 …