Engineering interventions in industrial filamentous fungal cell factories for biomass valorization

A Madhavan, KB Arun, R Sindhu, AA Jose… - Bioresource …, 2022 - Elsevier
Filamentous fungi possess versatile capabilities for synthesizing a variety of valuable bio
compounds, including enzymes, organic acids and small molecule secondary metabolites …

Total Heterologous Biosynthesis of Fungal Natural Products in Aspergillus nidulans

YM Chiang, TS Lin, CCC Wang - Journal of natural products, 2022 - ACS Publications
Fungal natural products comprise a wide range of bioactive compounds including important
drugs and agrochemicals. Intriguingly, bioinformatic analyses of fungal genomes have …

[HTML][HTML] Promoter regulation and genetic engineering strategies for enhanced cellulase expression in Trichoderma reesei

M Adnan, X Ma, S Olsson, J Wang, G Liu - Microbiological Research, 2022 - Elsevier
Background Trichoderma reesei has extraordinary potential for high-level protein production
at large scales, and it need to be further explored through genetic engineering tools to …

[HTML][HTML] Evaluation of Aspergillus niger Six Constitutive Strong Promoters by Fluorescent-Auxotrophic Selection Coupled with Flow Cytometry: A Case for Citric Acid …

Y Lu, X Zheng, Y Wang, L Zhang, L Wang, Y Lei… - Journal of Fungi, 2022 - mdpi.com
Aspergillus niger is an important industrial workhorse for the biomanufacturing of organic
acids, proteins, etc. Well-controlled genetic regulatory elements, including promoters, are …

Plant‐associated endophytic fungi as potential bio‐factories for extracellular enzymes: Progress, Challenges and Strain improvement with precision approaches

D Raghav, A Jyoti, AJ Siddiqui… - Journal of Applied …, 2022 - academic.oup.com
There is an intricate network of relations between endophytic fungi and their hosts that
affects the production of various bioactive compounds. Plant‐associated endophytic fungi …

[HTML][HTML] Integrative transcriptome and proteome analyses of Trichoderma longibrachiatum LC and its cellulase hyper-producing mutants generated by heavy ion …

M Dong, S Wang, F Xu, G Xiao, J Bai, J Wang… - … for Biofuels and …, 2022 - Springer
Background The major challenge of facing the efficient utilization of biomass is the high cost
of cellulolytic enzyme, while the Trichoderma longibrachiatum plays an essential role in the …

Homologous Expression and Characterization of α-L-rhamnosidase from Aspergillus niger for the Transformation of Flavonoids

H Ye, X Li, L Li, Y Zhang, J Zheng - Applied Biochemistry and …, 2022 - Springer
Aspergillus niger has been used for homologous and heterologous expressions of many
protein products. In this study, the α-L-rhamnosidase from A. niger (Rha-N1, GenBank …

Construction of a novel filamentous fungal protein expression system based on redesigning of regulatory elements

Z Zhang, B Xiang, S Zhao, L Yang, Y Chen… - Applied Microbiology …, 2022 - Springer
Filamentous fungi are extensively used as an important expression host for the production of
a variety of essential industrial proteins. They have significant promise as an expression …

Exploring a novel genomic safe-haven site in the human pathogenic mould Aspergillus fumigatus

T Furukawa, N van Rhijn, H Chown, J Rhodes… - Fungal Genetics and …, 2022 - Elsevier
Aspergillus fumigatus is the most important airborne fungal pathogen and allergen of
humans causing high morbidity and mortality worldwide. The factors that govern …

[HTML][HTML] A novel potent carrier for unconventional protein export in ustilago maydis

M Philipp, KP Hussnaetter, M Reindl… - Frontiers in Cell and …, 2022 - frontiersin.org
Recombinant proteins are ubiquitously applied in fields like research, pharma, diagnostics
or the chemical industry. To provide the full range of useful proteins, novel expression hosts …