[HTML][HTML] Biological characteristics and clinical significance of soluble PD-1/PD-L1 and exosomal PD-L1 in cancer
M Niu, Y Liu, M Yi, D Jiao, K Wu - Frontiers in Immunology, 2022 - frontiersin.org
The immune checkpoint pathway consisting of the cell membrane-bound molecule
programmed death protein 1 (PD-1) and its ligand PD-L1 has been found to mediate …
programmed death protein 1 (PD-1) and its ligand PD-L1 has been found to mediate …
[HTML][HTML] TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy
M Yi, T Li, M Niu, Y Wu, Z Zhao, K Wu - Frontiers in Immunology, 2022 - frontiersin.org
Transforming growth factor-β (TGF-β) signaling regulates multiple physiological processes,
such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides …
such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides …
[HTML][HTML] Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic …
S Serratì, M Guida, R Di Fonte, S De Summa… - Molecular Cancer, 2022 - Springer
Background The immunotherapy with immune checkpoints inhibitors (ICI) has changed the
life expectancy in metastatic melanoma (MM) patients. Nevertheless, several patients do not …
life expectancy in metastatic melanoma (MM) patients. Nevertheless, several patients do not …
[HTML][HTML] Extracellular vesicle PD-L1 dynamics predict durable response to immune-checkpoint inhibitors and survival in patients with non-small cell lung cancer
Abstract Background Immune-checkpoint inhibitors (ICIs) changed the therapeutic
landscape of patients with lung cancer. However, only a subset of them derived clinical …
landscape of patients with lung cancer. However, only a subset of them derived clinical …
[HTML][HTML] Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management
L Peng, Y Chen, S Shi, H Wen - Stem Cell Research & Therapy, 2022 - Springer
Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent
years, it remains the most common cause of end-stage renal disease. An early diagnosis …
years, it remains the most common cause of end-stage renal disease. An early diagnosis …
[HTML][HTML] Macitentan improves antitumor immune responses by inhibiting the secretion of tumor-derived extracellular vesicle PD-L1
CH Lee, JH Bae, EJ Choe, JM Park, SS Park… - Theranostics, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) carrying tumor cell-derived programmed death-ligand 1 (PD-L1)
interact with programmed death 1 (PD-1)-producing T cells, thus significantly lowering a …
interact with programmed death 1 (PD-1)-producing T cells, thus significantly lowering a …
Aptamer-assisted traceless isolation of PD-L1-positive small extracellular vesicles for dissecting their subpopulation signature and function
R Xu, ZL Yu, XC Liu, QH Xie, M Wu… - Analytical Chemistry, 2022 - ACS Publications
Small extracellular vesicles (sEVs) are heterogeneous membrane-bound vesicles that carry
numerous bioactive molecules. Studies have reported that sEVs carrying PD-L1 on the …
numerous bioactive molecules. Studies have reported that sEVs carrying PD-L1 on the …
[HTML][HTML] The role of extracellular vesicles in metabolic reprogramming of the tumor microenvironment
ES Fridman, L Ginini, Z Gil - Cells, 2022 - mdpi.com
The tumor microenvironment (TME) includes a network of cancerous and non-cancerous
cells, together with associated blood vessels, the extracellular matrix, and signaling …
cells, together with associated blood vessels, the extracellular matrix, and signaling …
Engineered small extracellular vesicles as a FGL1/PD‐L1 dual‐targeting delivery system for alleviating immune rejection
H Tsai, Y Wu, X Liu, Z Xu, L Liu, C Wang… - Advanced …, 2022 - Wiley Online Library
There is an urgent need for developing new immunosuppressive agents due to the toxicity of
long‐term use of broad immunosuppressive agents after organ transplantation …
long‐term use of broad immunosuppressive agents after organ transplantation …
Lactobacillus kefiranofaciens ZW18 from Kefir enhances the anti-tumor effect of anti-programmed cell death 1 (PD-1) immunotherapy by modulating the gut microbiota
J Zhao, Y Wang, J Wang, M Lv, C Zhou, L Jia… - Food & Function, 2022 - pubs.rsc.org
Research on probiotics assisting PD-1 inhibitors in anti-tumor therapy has attracted
widespread attention. Therefore, it is important to find new probiotic strains with a PD-1 …
widespread attention. Therefore, it is important to find new probiotic strains with a PD-1 …