Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …

OPA1 and MICU1 are both involved in the regulation of mitochondrial Ca 2+ uptake and the
stabilization of the cristae junction, which separates the inner mitochondrial membrane into …

Mitochondrial ultrastructure represents a pinnacle of form and function, with the inner
mitochondrial membrane (IMM) forming isolated pockets of cristae membrane (CM) …

Toxins present in cigarette and e-cigarette smoke constitute a significant cause of illnesses
and are known to have fatal health impacts. Specific mechanisms by which toxins present in …

Developing methods to improve the regenerative capacity of somatic stem cells (SSCs) is a
major challenge in regenerative medicine. Here, we propose the forced expression of …

Mitochondrial dynamics encompass mitochondrial fusion, fission, and movement.
Mitochondrial fission and fusion are seemingly ubiquitous, whereas mitochondrial …

The purpose of this study was to evaluate the neuroprotective effects of omega-3
polyunsaturated fatty acid (ω3-PUFA) supplementation in a mouse model of OPA1 …

Autosomal dominant optic atrophy (DOA) is the most common inherited optic neuropathy,
characterized by the preferential loss of retinal ganglion cells (RGCs), resulting in optic …

The nervous system is the central hub of the body, detecting environmental and internal
stimuli to regulate organismal metabolism via communications to the peripheral tissues …

Exonic (ie coding) variants in genes associated with disease can exert pathogenic effects
both at the protein and mRNA level, either by altering the amino acid sequence or by …