The biology of ependymomas and emerging novel therapies

AH Saleh, N Samuel, K Juraschka, MH Saleh… - Nature Reviews …, 2022 - nature.com
Ependymomas are rare central nervous system tumours that can arise in the brain's
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …

The oncogenic fusion landscape in pediatric CNS neoplasms

M Roosen, Z Odé, J Bunt, M Kool - Acta Neuropathologica, 2022 - Springer
Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-
related deaths in children. Recent developments in molecular analyses have greatly …

[HTML][HTML] Ependymomas

L Bertero, AA Ricci, C Tampieri, P Cassoni… - Pathologica, 2022 - ncbi.nlm.nih.gov
Ependymal neoplasms are a heterogenous group of neoplasms arising from the progenitors
of the cells lining the ventricular system and the spinal central canal. During the last few …

Diffusely infiltrating glioma with CREBBP–BCORL1 fusion showing overexpression of not only BCORL1 but BCOR: A case report

A Yamazaki, Y Arai, K Fukuoka, Y Nakano… - Brain Tumor …, 2022 - Springer
BCORL1 encodes a transcriptional corepressor homolog to BCOR. BCORL1
rearrangements have been previously described as rare events, and among them, CREBBP …

Bevacizumab beyond progression for newly diagnosed glioblastoma (BIOMARK): phase II safety, efficacy and biomarker study

M Nagane, K Ichimura, R Onuki, D Narushima… - Cancers, 2022 - mdpi.com
Simple Summary This was a multicenter, single-arm, phase II study comprising two protocol
treatments. Patients were enrolled after craniotomy or biopsy and initiated the concurrent …

Molecular subgrouping of ependymoma across three anatomic sites and their prognostic implications

D Chinnam, K Gupta, T Kiran, A Saraswati… - Brain Tumor …, 2022 - Springer
The 2021 WHO classification stratifies ependymoma (EPN) into nine molecular subgroups
according to the anatomic locations which outperforms histological grading. We aimed at …

ZFTA (zinc finger translocation associated) fusion in supratentorial ependymomas: low prevalence in South Asians and no correlation with survival

A Goyal-Honavar, A Balasundaram, IP Thayakaran… - World Neurosurgery, 2022 - Elsevier
Background Supratentorial ependymomas (STEs) are an aggressive group of
ependymomas, topographically distinct from their posterior fossa and spinal counterparts …

[HTML][HTML] Pigmented ependymoma, a tumor with predilection for the middle-aged adult: case report with methylation classification and review of 16 literature cases

AS Himstead, M Perez-Rosendahl, GM Fote… - Free …, 2022 - ncbi.nlm.nih.gov
Ependymomas have rarely been described to contain pigment other than melanin,
neuromelanin, lipofuscin or a combination. In this case report, we present a pigmented …

[PDF][PDF] Mutation profiling of anaplastic ependymoma grade III by Ion

M Butt, S Alyami, T Nageeti, M Saeed, K AlQuthami… - academia.edu
Ependymomas are glial tumors derived from differentiated Background: ependymal cells. In
contrast to other types of brain tumors, histological grading is not a good prognostic marker …