A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo

A Dong, K He, B Dudok, JS Farrell, W Guan… - Nature …, 2022 - nature.com
Endocannabinoids (eCBs) are retrograde neuromodulators with important functions in a
wide range of physiological processes, but their in vivo dynamics remain largely …

[HTML][HTML] The Potential Role of Polyamines in Epilepsy and Epilepsy-Related Pathophysiological Changes

J Liu, Z Yu, B Maimaiti, Q Meng, H Meng - Biomolecules, 2022 - mdpi.com
Epilepsy is one of the most common neurological disorders and severely impacts the life
quality of patients. Polyamines are ubiquitous, positively charged aliphatic amines that are …

[HTML][HTML] Volumetric and structural connectivity abnormalities co-localise in TLE

JJ Horsley, GM Schroeder, RH Thomas, J de Tisi… - NeuroImage: Clinical, 2022 - Elsevier
Patients with temporal lobe epilepsy (TLE) exhibit both volumetric and structural connectivity
abnormalities relative to healthy controls. How these abnormalities inter-relate and their …

[HTML][HTML] Brain tissue oxygen dynamics while mimicking the functional deficiency of interneurons

DP Aksenov, ED Doubovikov… - Frontiers in Cellular …, 2022 - frontiersin.org
The dynamic interaction between excitatory and inhibitory activity in the brain is known as
excitatory-inhibitory balance (EIB). A significant shift in EIB toward excitation has been …

Electrographic seizures and brain hyperoxia may be key etiological factors for postconcussive deficits

H Malik, MD Wolff, GC Teskey… - Journal of …, 2022 - journals.physiology.org
Repetitive mild traumatic brain injuries (RmTBIs) are increasingly recognized to have long-
term neurological sequelae in a significant proportion of patients. Individuals that have had …

[HTML][HTML] Sulforaphane ameliorates metabolic changes associated with status epilepticus in immature rats

J Daněk, Š Danačíková, D Kala, J Svoboda… - Frontiers in Cellular …, 2022 - frontiersin.org
Status epilepticus (SE) is a common paediatric emergency with the highest incidence in the
neonatal period and is a well-known epileptogenic insult. As previously established in …

Febrile seizures lead to prolonged epileptiform activity and hyperoxia that when blocked prevents learning deficits

SA Harris, AG George, KT Barrett, MH Scantlebury… - …, 2022 - Wiley Online Library
Objective In adult brain tissue, oxygen levels typically remain in the normoxic zone, but
status epilepticus results in hyperoxia, whereas brief self‐terminating seizures lead to …

[HTML][HTML] How can we distinguish postictal Todd's Paralysis from acute ischemic stroke in the prehospital and early hospital setting?

N Blek - Journal of Epileptology, 2022 - sciendo.com
Aim This review discusses Todd's post-epileptic paralysis, one of the most common acute
ischemic stroke (AIS) mimics, in pre-and early-hospital settings. Materials and Methods This …

[HTML][HTML] Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE)

JPAJ Verdijk, JCM Pottkämper, E Verwijk… - Trials, 2022 - Springer
Background Postictal phenomena as delirium, headache, nausea, myalgia, and
anterograde and retrograde amnesia are common manifestations after seizures induced by …

Growth and differentiation factor-15 as a potential prognostic biomarker for status-epilepticus-associated-with-fever: A pilot study

H Yamaguchi, M Nishiyama, K Tomioka, H Hongo… - Brain and …, 2022 - Elsevier
Objective Biomarkers predicting poor outcomes of status-epilepticus-associated-with-fever
(SEF) at an early stage may contribute to treatment guidance. However, none have been …