Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial

MT Smith - Pain, 2022 - journals.lww.com
Globally, the prevalence of chronic pain is high at 10% to 50% of the adult population. 18,
23, 40, 57, 63, 64 Chronic pain not only impairs the quality of life of patients and their …

Beyond PD-1/PD-L1 Immune Checkpoint Inhibitors: Other Targets and Approaches for Head and Neck Cancer

N Gavrielatou, P Economopoulou, A Psyrri - Immunotherapy for Head and …, 2022 - Springer
Immunotherapy has reshaped the treatment landscape of head and neck cancer (HNC) in
recent years, as it has become standard of care for advanced disease. Despite initial …

Methods of Mutational Signature Analysis for Discovery, Comparison, and Drug Response Prediction

A Chevalier - 2022 - search.proquest.com
This dissertation proposes tools and analysis of mutational signatures in human cancer and
their application to the stratification of patients for drug response. To provide a …

Allometric and fluctuation scaling in health, well-being and mortality

J Sutton - 2022 - irep.ntu.ac.uk
In the urban scaling hypothesis, it has been noted that cities exhibit self-similar behaviour.
Much of the scaling literature focuses on cities, whilst not including rural regions. Initially …