Plasmodium vivax is the most widespread causative agent of human malaria in the world.
Despite the ongoing implementation of malaria control programs, the rate of case reduction …

Investigation of the diversity of malaria parasite antigens can help prioritize and validate
them as vaccine candidates and identify the most common variants for inclusion in vaccine …

Undetected subclinical Plasmodium spp. infections are a significant barrier to eliminating
malaria. In malaria-endemic areas, naturally acquired antimalarial antibodies develop with …

Background Protective malarial antibodies are acquired more rapidly in adults than children,
independently of cumulative exposure, however the cellular responses mediating these …

T-follicular helper (Tfh) cells are key drivers of antibodies that protect from malaria. However,
little is known regarding the host and parasite factors that influence Tfh and functional …

Memory B cells (MBCs) and plasma antibodies against Plasmodium falciparum (Pf)
merozoite antigens are important components of the protective immune response against …

The pathogenesis of malaria is associated with blood-stage infection and there is strong
evidence that antibodies specific to parasite blood-stage antigens can control parasitemia …

Controlled human malaria challenge studies in semi-immune volunteers provide an
unparalleled opportunity to robustly identify mechanistic correlates of protection. We …

The complement system exerts crucial functions both in innate immune responses and
adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen …

Novel approaches for malaria prophylaxis remain important. Synthetic DNA-encoded
monoclonal antibodies (DMAbs) are a promising approach to generate rapid, direct in vivo …