[HTML][HTML] The burden and risks of emerging complications of diabetes mellitus

D Tomic, JE Shaw, DJ Magliano - Nature Reviews Endocrinology, 2022 - nature.com
The traditional complications of diabetes mellitus are well known and continue to pose a
considerable burden on millions of people living with diabetes mellitus. However, advances …

[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?

CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes—2022

American Diabetes Association Professional … - Diabetes …, 2022 - Am Diabetes Assoc
The American Diabetes Association (ADA)“Standards of Medical Care in Diabetes” includes
the ADA's current clinical practice recommendations and is intended to provide the …

TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer

S Shang, Y Yang, F Chen, L Yu, S Shen, K Li… - Science Translational …, 2022 - science.org
High CD8+ T cell infiltration in colorectal cancer (CRC) should suggest a favorable
prognosis and a satisfactory response to immunotherapy; however, the vast majority of …

Annual report to the nation on the status of cancer, part 1: National cancer statistics

KA Cronin, S Scott, AU Firth, H Sung, SJ Henley… - Cancer, 2022 - Wiley Online Library
Abstract Background The American Cancer Society, the Centers for Disease Control and
Prevention, the National Cancer Institute, and the North American Association of Central …

Association of bariatric surgery with cancer incidence in patients with obesity and diabetes: long-term results from the Swedish obese subjects study

K Sjöholm, LMS Carlsson, PA Svensson… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE Obesity and type 2 diabetes are associated with serious adverse health effects,
including cancer. Although bariatric surgery has been shown to reduce cancer risk in …

[HTML][HTML] Mechanisms that regulate the activities of TET proteins

K Joshi, S Liu, P Breslin SJ, J Zhang - Cellular and Molecular Life Sciences, 2022 - Springer
The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …

Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening

W Wang, LA Hapach, L Griggs, K Smart, Y Wu… - Science …, 2022 - science.org
Diabetes mellitus is a complex metabolic disorder that is associated with an increased risk of
breast cancer. Despite this correlation, the interplay between tumor progression and …

[HTML][HTML] Baicalin suppresses the progression of Type 2 diabetes-induced liver tumor through regulating METTL3/m6A/HKDC1 axis and downstream p-JAK2/STAT1 …

H Jiang, Q Yao, Y An, L Fan, J Wang, H Li - Phytomedicine, 2022 - Elsevier
Background Epidemiological and clinical evidence suggests that diabetes increases the risk
of liver cancer. Although the co-occurrence of type 2 diabetes (T2D) and liver cancer is …

[HTML][HTML] Sarcopenia as an independent risk factor for specific cancers: a propensity score-matched Asian population-based cohort study

MY Sun, CL Chang, CY Lu, SY Wu, JQ Zhang - Nutrients, 2022 - mdpi.com
Simple Summary Whether preexisting sarcopenia independently leads to cancer incidence
remains unclear. Our study investigated the effect of sarcopenia on cancer incidence. We …