JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
The JAK/STAT pathway and its selective inhibition in the treatment of atopic dermatitis: a systematic review
A Tsiogka, M Kyriazopoulou… - Journal of Clinical …, 2022 - mdpi.com
In recent years, the broadening understanding of the pathogenesis of atopic dermatitis (AD)
has led to the development of novel therapeutic molecules, that target core inflammatory …
has led to the development of novel therapeutic molecules, that target core inflammatory …
New topical therapies in development for atopic dermatitis
E Freitas, M Gooderham, T Torres - Drugs, 2022 - Springer
Atopic dermatitis (AD) is a common chronic pruritic inflammatory cutaneous disease. AD is
characterized by intense pruritus and enormous clinical heterogeneity. Treatment goals are …
characterized by intense pruritus and enormous clinical heterogeneity. Treatment goals are …
Baicalin ameliorates 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice through modulating skin barrier function, gut microbiota and JAK …
Baicalin has distinct therapeutic effects in various skin diseases animal models such as
atopic dermatitis (AD) and psoriasis. In this study, we aimed to investigate the anti-atopic …
atopic dermatitis (AD) and psoriasis. In this study, we aimed to investigate the anti-atopic …
Emerging role for thymic stromal lymphopoietin–responsive regulatory T cells in colorectal cancer progression in humans and mice
K Obata-Ninomiya, S de Jesus Carrion, A Hu… - Science Translational …, 2022 - science.org
Recruitment of regulatory T cells (Tregs) to tumors is a hallmark of cancer progression.
Tumor-derived factors, such as the cytokine thymic stromal lymphopoietin (TSLP), can …
Tumor-derived factors, such as the cytokine thymic stromal lymphopoietin (TSLP), can …
Pharmacodynamics of Janus kinase inhibitors for the treatment of atopic dermatitis
L Calabrese, A Chiricozzi, C De Simone… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Atopic dermatitis (AD) is the most common inflammatory skin disorder. Despite
the high disease burden, the therapeutic options are limited and their efficacy in controlling …
the high disease burden, the therapeutic options are limited and their efficacy in controlling …
Neuro–epithelial–ILC2 crosstalk in barrier tissues
Z Yin, Y Zhou, HR Turnquist, Q Liu - Trends in Immunology, 2022 - cell.com
Group 2 innate lymphoid cells (ILC2s) contribute to the maintenance of mammalian barrier
tissue homeostasis. We review how ILC2s integrate epithelial signals and neurogenic …
tissue homeostasis. We review how ILC2s integrate epithelial signals and neurogenic …
Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL
K Sasaki, T Yamauchi, Y Semba… - Blood, The Journal …, 2022 - ashpublications.org
Acute lymphoblastic leukemia (ALL) harboring the IgH-CRLF2 rearrangement (IgH-CRLF2-
r) exhibits poor clinical outcomes and is the most common subtype of Philadelphia …
r) exhibits poor clinical outcomes and is the most common subtype of Philadelphia …
Genetic/environmental contributions and immune dysregulation in children with atopic dermatitis
AC Chong, K Visitsunthorn, PY Ong - Journal of Asthma and …, 2022 - Taylor & Francis
Atopic dermatitis (AD) is one of the most common skin conditions in humans. AD affects up
to 20% of children worldwide and results in morbidity for both patients and their caregivers …
to 20% of children worldwide and results in morbidity for both patients and their caregivers …
The role of airway epithelial cell alarmins in asthma
The airway epithelium is the first line of defense for the lungs, detecting inhaled
environmental threats through pattern recognition receptors expressed transmembrane or …
environmental threats through pattern recognition receptors expressed transmembrane or …