JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review

IH Huang, WH Chung, PC Wu, CB Chen - Frontiers in immunology, 2022 - frontiersin.org
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …

The JAK/STAT pathway and its selective inhibition in the treatment of atopic dermatitis: a systematic review

A Tsiogka, M Kyriazopoulou… - Journal of Clinical …, 2022 - mdpi.com
In recent years, the broadening understanding of the pathogenesis of atopic dermatitis (AD)
has led to the development of novel therapeutic molecules, that target core inflammatory …

New topical therapies in development for atopic dermatitis

E Freitas, M Gooderham, T Torres - Drugs, 2022 - Springer
Atopic dermatitis (AD) is a common chronic pruritic inflammatory cutaneous disease. AD is
characterized by intense pruritus and enormous clinical heterogeneity. Treatment goals are …

Baicalin ameliorates 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice through modulating skin barrier function, gut microbiota and JAK …

L Wang, YF Xian, SKF Loo, SP Ip, W Yang… - Bioorganic …, 2022 - Elsevier
Baicalin has distinct therapeutic effects in various skin diseases animal models such as
atopic dermatitis (AD) and psoriasis. In this study, we aimed to investigate the anti-atopic …

Emerging role for thymic stromal lymphopoietin–responsive regulatory T cells in colorectal cancer progression in humans and mice

K Obata-Ninomiya, S de Jesus Carrion, A Hu… - Science Translational …, 2022 - science.org
Recruitment of regulatory T cells (Tregs) to tumors is a hallmark of cancer progression.
Tumor-derived factors, such as the cytokine thymic stromal lymphopoietin (TSLP), can …

Pharmacodynamics of Janus kinase inhibitors for the treatment of atopic dermatitis

L Calabrese, A Chiricozzi, C De Simone… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Atopic dermatitis (AD) is the most common inflammatory skin disorder. Despite
the high disease burden, the therapeutic options are limited and their efficacy in controlling …

Neuro–epithelial–ILC2 crosstalk in barrier tissues

Z Yin, Y Zhou, HR Turnquist, Q Liu - Trends in Immunology, 2022 - cell.com
Group 2 innate lymphoid cells (ILC2s) contribute to the maintenance of mammalian barrier
tissue homeostasis. We review how ILC2s integrate epithelial signals and neurogenic …

Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL

K Sasaki, T Yamauchi, Y Semba… - Blood, The Journal …, 2022 - ashpublications.org
Acute lymphoblastic leukemia (ALL) harboring the IgH-CRLF2 rearrangement (IgH-CRLF2-
r) exhibits poor clinical outcomes and is the most common subtype of Philadelphia …

Genetic/environmental contributions and immune dysregulation in children with atopic dermatitis

AC Chong, K Visitsunthorn, PY Ong - Journal of Asthma and …, 2022 - Taylor & Francis
Atopic dermatitis (AD) is one of the most common skin conditions in humans. AD affects up
to 20% of children worldwide and results in morbidity for both patients and their caregivers …

The role of airway epithelial cell alarmins in asthma

CE Whetstone, M Ranjbar, H Omer, RP Cusack… - Cells, 2022 - mdpi.com
The airway epithelium is the first line of defense for the lungs, detecting inhaled
environmental threats through pattern recognition receptors expressed transmembrane or …