[HTML][HTML] Tauopathies: new perspectives and challenges
Y Zhang, KM Wu, L Yang, Q Dong, JT Yu - Molecular neurodegeneration, 2022 - Springer
Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …
[HTML][HTML] From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer's and Parkinson's diseases
D Wakhloo, J Oberhauser, A Madira… - Neural regeneration …, 2022 - journals.lww.com
Two of the most common neurodegenerative disorders–Alzheimer's and Parkinson's
diseases–are characterized by synaptic dysfunction and degeneration that culminate in …
diseases–are characterized by synaptic dysfunction and degeneration that culminate in …
[HTML][HTML] Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy
Neuropathologic criteria for progressive supranuclear palsy (PSP) proposed by a National
Institute of Neurological Disorders and Stroke (NINDS) working group were published in …
Institute of Neurological Disorders and Stroke (NINDS) working group were published in …
Functional regulatory variants implicate distinct transcriptional networks in dementia
Predicting the function of noncoding variation is a major challenge in modern genetics. In
this study, we used massively parallel reporter assays to screen 5706 variants identified …
this study, we used massively parallel reporter assays to screen 5706 variants identified …
Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain
Structural variants (SVs), which are genomic rearrangements of more than 50 base pairs,
are an important source of genetic diversity and have been linked to many diseases …
are an important source of genetic diversity and have been linked to many diseases …
Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration
V Kluever, B Russo, S Mandad, NH Kumar… - Science …, 2022 - science.org
Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the
molecular mechanisms rendering the aged brain particularly susceptible to …
molecular mechanisms rendering the aged brain particularly susceptible to …
Common variants contribute to intrinsic human brain functional networks
The human brain forms functional networks of correlated activity, which have been linked
with both cognitive and clinical outcomes. However, the genetic variants affecting brain …
with both cognitive and clinical outcomes. However, the genetic variants affecting brain …
Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology
K Tsujikawa, K Hamanaka, Y Riku, Y Hattori… - Science …, 2022 - science.org
While amyloid-β lies upstream of tau pathology in Alzheimer's disease, key drivers for other
tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various …
tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various …
The emerging role of LRRK2 in tauopathies
Parkinson's disease (PD) is conventionally described as an α-synuclein aggregation
disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase …
disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase …
Genome-wide association study and functional validation implicates JADE1 in tauopathy
Primary age-related tauopathy (PART) is a neurodegenerative pathology with features
distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer …
distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer …