Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …

Objective Parental environmental exposures can strongly influence descendant risks for
adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition …

Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …

BACKGROUND Spermatozoa acquire their motility and fertilizing abilities during their
maturation through the epididymis. This process is controlled by epididymal epithelial cells …

Epigenetic information is transmitted from one generation to the next, modulating the
phenotype of offspring non-genetically in organisms ranging from plants to mammals. For …

Maternal immune activation (MIA) and infection during pregnancy are known to
reprogramme offspring phenotypes. However, the epigenetic effects of preconceptual …

Background Paternal lifestyle choices and male exposure history have a critical influence on
the health and fitness of the next generation. Accordingly, defining the processes of germline …

Background: DNA methylation (DNAme) and histone posttranslational modifications (PTMs)
play an integral role in the transcriptional regulation of specific sets of genes and …

The Valley of Sacco River (VSR)(Latium, Italy) is an area with large-scale industrial chemical
production that has led over time to significant contamination of soil and groundwater with …