Surface modification of lipid-based nanoparticles
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …
purposes, including the recent increase of these nanocarriers as vaccine components …
Nanodiscs: a versatile nanocarrier platform for cancer diagnosis and treatment
J Bariwal, H Ma, GA Altenberg, H Liang - Chemical Society Reviews, 2022 - pubs.rsc.org
Cancer therapy is a significant challenge due to insufficient drug delivery to the cancer cells
and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations …
and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations …
Glioma diagnosis and therapy: current challenges and nanomaterial-based solutions
Glioma is often referred to as one of the most dreadful central nervous system (CNS)-specific
tumors with rapidly-proliferating cancerous glial cells, accounting for nearly half of the brain …
tumors with rapidly-proliferating cancerous glial cells, accounting for nearly half of the brain …
Advancements in cell membrane camouflaged nanoparticles: A bioinspired platform for cancer therapy
The idea of employing natural cell membranes as a coating medium for nanoparticles (NPs)
endows man-made vectors with natural capabilities and benefits. In addition to retaining the …
endows man-made vectors with natural capabilities and benefits. In addition to retaining the …
[HTML][HTML] Modification of lipid-based nanoparticles: An efficient delivery system for nucleic acid-based immunotherapy
Lipid-based nanoparticles (LBNPs) are biocompatible and biodegradable vesicles that are
considered to be one of the most efficient drug delivery platforms. Due to the prominent …
considered to be one of the most efficient drug delivery platforms. Due to the prominent …
[HTML][HTML] Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort
Type 2 diabetes (T2D) and cardiovascular disease (CVD) represent significant disease
burdens for most societies and susceptibility to these diseases is strongly influenced by diet …
burdens for most societies and susceptibility to these diseases is strongly influenced by diet …
Scavenger receptor-targeted plaque delivery of microRNA-coated nanoparticles for alleviating atherosclerosis
Atherosclerosis treatments by gene regulation are garnering attention, yet delivery of gene
cargoes to atherosclerotic plaques remains inefficient. Here, we demonstrate that assembly …
cargoes to atherosclerotic plaques remains inefficient. Here, we demonstrate that assembly …
Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice
Sepsis is a major health issue with mortality exceeding 30% and few treatment options. We
found that high-density lipoprotein cholesterol (HDL-C) abundance was reduced by 45% in …
found that high-density lipoprotein cholesterol (HDL-C) abundance was reduced by 45% in …
[HTML][HTML] Advances in antitumor nano-drug delivery systems of 10-hydroxycamptothecin
Y Chen, Z Wang, X Wang, M Su, F Xu… - International Journal …, 2022 - ncbi.nlm.nih.gov
Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows
potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as …
potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as …
[HTML][HTML] Lenvatinib-and vadimezan-loaded synthetic high-density lipoprotein for combinational immunochemotherapy of metastatic triple-negative breast cancer
C Zheng, W Zhang, J Wang, Y Zhai, F Xiong… - … Pharmaceutica Sinica B, 2022 - Elsevier
Metastatic triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer.
Combination of systemic chemotherapy and immune checkpoint blockade is effective but of …
Combination of systemic chemotherapy and immune checkpoint blockade is effective but of …