Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about
forty years and to date MTX remains the part of global standard of treatment for RA. The …

Adenosine is an endogenous purine-based nucleoside expressed nearly in all body tissues.
It regulates various body functions by activating four G-protein coupled receptors, A 1, A 2A …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and
even disability. Although there are various clinical therapies for RA, some patients still have …

ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) are a revolutionary form of
immunotherapy in cancer. However, the percentage of patients responding to therapy is …

Placenta‐specific molecular basis that is responsible for the pathophysiology of
preeclampsia (PE) remains to be fully understood. Adenosine, an endogenous nucleoside …

1.1 Современные взгляды о значении эндогенной интоксикации в патогенезе
рака…………………………………………………… 1.2 Особенности эритропоэза и …