Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Revisiting the virulence hallmarks of Pseudomonas aeruginosa: a chronicle through the perspective of quorum sensing

J Chadha, K Harjai, S Chhibber - Environmental microbiology, 2022 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …

Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa

LZ Ma, D Wang, Y Liu, Z Zhang… - Annual review of …, 2022 - annualreviews.org
Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the
natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms …

[HTML][HTML] Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

R Yin, J Cheng, J Wang, P Li, J Lin - Frontiers in Microbiology, 2022 - frontiersin.org
Pseudomonas aeruginosa, a Gram-negative bacterium, is one of the major pathogens
implicated in human opportunistic infection and a common cause of clinically persistent …

Genetic regulation, biosynthesis and applications of extracellular polysaccharides of the biofilm matrix of bacteria

S Das - Carbohydrate polymers, 2022 - Elsevier
Bacterial biofilm formation is dependent mainly on the decision-making process of the two
key factors of the gene regulatory network, namely the Quorum Sensing (QS) system and bis …

[HTML][HTML] The evolutionary origin of host association in the Rickettsiales

ME Schön, J Martijn, J Vosseberg, S Köstlbacher… - Nature …, 2022 - nature.com
The evolution of obligate host-association of bacterial symbionts and pathogens remains
poorly understood. The Rickettsiales are an alphaproteobacterial order of obligate …

[HTML][HTML] Development of antibiofilm therapeutics strategies to overcome antimicrobial drug resistance

S Nadar, T Khan, SG Patching, A Omri - Microorganisms, 2022 - mdpi.com
A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix
produced by themselves. Many types of microorganisms that are found on living hosts or in …

A dissolving microneedle patch for antibiotic/enzymolysis/photothermal triple therapy against bacteria and their biofilms

X Yu, J Zhao, D Fan - Chemical Engineering Journal, 2022 - Elsevier
The biofilms present in wounds are difficult to eliminate due to the compact barrier formed by
extracellular polymeric substances (EPS). Herein, we have designed a dissolvable …

[HTML][HTML] A critical review of marine biofilms on metallic materials

B Tuck, E Watkin, A Somers, LL Machuca - npj Materials degradation, 2022 - nature.com
The formation of multi-species biofilms on marine infrastructure costs the global economy
US $ billions annually, resulting in biofouling and microbiologically influenced corrosion. It is …

[HTML][HTML] The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine

F Le Mauff, E Razvi, C Reichhardt, P Sivarajah… - Communications …, 2022 - nature.com
The genetic capacity to synthesize the biofilm matrix exopolysaccharide Pel is widespread
among Gram-negative and Gram-positive bacteria. However, its exact chemical structure …