Genetic generalized epilepsies in adults—challenging assumptions and dogmas

BJ Vorderwülbecke, B Wandschneider… - Nature Reviews …, 2022 - nature.com
Genetic generalized epilepsy (GGE) syndromes start during childhood or adolescence, and
four commonly persist into adulthood, making up 15–20% of all cases of epilepsy in adults …

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

S Larivière, J Royer, R Rodríguez-Cruces… - Nature …, 2022 - nature.com
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations,
but associations between neurobiological mechanisms and macroscale connectomics …

Drug resistance in idiopathic generalized epilepsies: Evidence and concepts

J Gesche, CP Beier - Epilepsia, 2022 - Wiley Online Library
Abstract Although approximately 10%–15% of patients with idiopathic generalized epilepsy
(IGE)/genetic generalized epilepsy remain drug‐resistant, there is no consensus or …

Relay and higher-order thalamic nuclei show an intertwined functional association with cortical-networks

VJ Kumar, CF Beckmann, K Scheffler… - Communications …, 2022 - nature.com
Almost all functional processing in the cortex strongly depends on thalamic interactions.
However, in terms of functional interactions with the cerebral cortex, the human thalamus …

Episodic memory network connectivity in temporal lobe epilepsy

M Fleury, S Buck, LP Binding, L Caciagli, SB Vos… - …, 2022 - Wiley Online Library
Objective Temporal lobe epilepsy (TLE) affects brain networks and is associated with
impairment of episodic memory. Temporal and extratemporal reorganization of memory …

Centromedian nucleus of the thalamus deep brain stimulation for genetic generalized epilepsy: a case report and review of literature

S Agashe, D Burkholder, K Starnes… - Frontiers in Human …, 2022 - frontiersin.org
There is a paucity of treatment options for cognitively normal individuals with drug resistant
genetic generalized epilepsy (GGE). Centromedian nucleus of the thalamus (CM) deep …

[HTML][HTML] Development and validation of MRI-based radiomics models for diagnosing juvenile myoclonic epilepsy

KM Kim, H Hwang, B Sohn, K Park, K Han… - Korean Journal of …, 2022 - ncbi.nlm.nih.gov
Objective Radiomic modeling using multiple regions of interest in MRI of the brain to
diagnose juvenile myoclonic epilepsy (JME) has not yet been investigated. This study aimed …

Aberrant dynamic structure–function relationship of rich‐club organization in treatment‐naïve newly diagnosed juvenile myoclonic epilepsy

G Liu, W Zheng, H Liu, M Guo, L Ma, W Hu… - Human brain …, 2022 - Wiley Online Library
Neuroimaging studies have shown that juvenile myoclonic epilepsy (JME) is characterized
by impaired brain networks. However, few studies have investigated the potential …

More than just statics: Static and temporal dynamic changes in intrinsic brain activity in unilateral temporal lobe epilepsy

C Song, X Zhang, S Han, K Ma, K Wang… - Frontiers in Human …, 2022 - frontiersin.org
Background Temporal lobe epilepsy (TLE) is the most prevalent refractory focal epilepsy
and is more likely accompanied by cognitive impairment. The fully understanding of the …

Altered structural brain networks in refractory and nonrefractory idiopathic generalized epilepsy

A McKavanagh, BAK Kreilkamp, Y Chen… - Brain …, 2022 - liebertpub.com
Introduction: Idiopathic generalized epilepsy (IGE) is a collection of generalized nonlesional
epileptic network disorders. Around 20–40% of patients with IGE are refractory to antiseizure …