[HTML][HTML] Macrophages in renal injury, repair, fibrosis following acute kidney injury and targeted therapy
H Chen, N Liu, S Zhuang - Frontiers in immunology, 2022 - frontiersin.org
Acute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently,
there are no targeted therapeutics for preventing and treating AKI. Macrophages, important …
there are no targeted therapeutics for preventing and treating AKI. Macrophages, important …
[HTML][HTML] Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
C van Geffen, C Heiss, A Deißler… - Frontiers in …, 2022 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent
suppressive and regulative properties. MDSCs' strong immunosuppressive potential creates …
suppressive and regulative properties. MDSCs' strong immunosuppressive potential creates …
Targeting Inhibition of Accumulation and Function of Myeloid‐Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti‐PD …
M Zhang, L Wang, W Liu, T Wang… - Journal of …, 2022 - Wiley Online Library
Despite the remarkable success and efficacy of immune checkpoint blockade (ICB) therapy
such as anti‐PD‐L1 antibody in treating cancers, myeloid‐derived suppressor cells …
such as anti‐PD‐L1 antibody in treating cancers, myeloid‐derived suppressor cells …
[HTML][HTML] Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR
B Lee, SJ Park, S Lee, J Lee, E Lee, ES Yoo… - Cell death & …, 2022 - nature.com
Autophagy is a biological process that maintains cellular homeostasis and regulates the
internal cellular environment. Hyperactivating autophagy to trigger cell death has been a …
internal cellular environment. Hyperactivating autophagy to trigger cell death has been a …
[HTML][HTML] Local and systemic injections of human cord blood myeloid-derived suppressor cells to prevent graft rejection in corneal transplantation
J Lee, HJ Sohn, CH Kim, TG Kim, HS Lee - Biomedicines, 2022 - mdpi.com
Myeloid-derived suppressor cells (MDSCs) are therapeutic agents to prevent graft rejection
in organ transplants by modulating inflammation. Herein, the immunosuppressive effect of …
in organ transplants by modulating inflammation. Herein, the immunosuppressive effect of …
Integration of transcriptomics and metabolomics reveals pathways involved in MDSC supernatant attenuation of TGF-β1-induced myofibroblastic differentiation of …
YC Cheuk, X Niu, Y Mao, J Li, J Wang, S Xu… - Cell and Tissue …, 2022 - Springer
Overexposure to transforming growth factor b1 (TGF-β1) induces myofibroblastic
differentiation of mesenchymal stem cells (MSCs), which could be attenuated by myeloid …
differentiation of mesenchymal stem cells (MSCs), which could be attenuated by myeloid …
[HTML][HTML] Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
L Leonardo, E Kenangalem, JR Poespoprodjo… - Malaria Journal, 2022 - Springer
Background Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive
function are increased in human experimental Plasmodium falciparum infection, but have …
function are increased in human experimental Plasmodium falciparum infection, but have …
[HTML][HTML] Butyrate impeded the conscription of MDSCs to reduce CAC formation by blocking the TLR2 signaling pathway
T Xiao, M Sun, Y Chang, J Kang, C Zhao, R Zhu… - Journal of Functional …, 2022 - Elsevier
This study focuses on how butyrate alleviates CAC simulated by AOM-DSS through TLR2
signals and MDSCs, which is still unclear. Our results revealed that butyrate slowed …
signals and MDSCs, which is still unclear. Our results revealed that butyrate slowed …
[HTML][HTML] MDSCs participate in the pathogenesis of diffuse pulmonary hemorrhage in murine lupus through mTOR-FoxO1 signaling
L Tan, G Shi, J Zhao, X Xia, D Li, S Wang… - … and Biophysics Reports, 2022 - Elsevier
Diffuse pulmonary hemorrhage (DPH) is a common respiratory complication in patients with
systemic lupus erythematosus (SLE). Our previous study found that myeloid-derived …
systemic lupus erythematosus (SLE). Our previous study found that myeloid-derived …
[HTML][HTML] Regulation networks of non-Coding RNA-Associated ceRnas in cisplatin-induced acute kidney injury
Y Ding, S Wan, W Liu, Y Lu, Q Xu, Y Gan, L Yan, Y Gu… - Cells, 2022 - mdpi.com
Cisplatin is widely used as a chemotherapeutic drug to treat various solid tumors. However,
it often induces severe side effects, including nephrotoxicity, which limits its application in …
it often induces severe side effects, including nephrotoxicity, which limits its application in …