Simple Summary Presently, the study of cancer stem cells is important because these cells
increase the cancer complexity, confer tumors the ability to grow, resist treatment, and …

We recently reported a potent, selective, and in vivo efficacious AKT degrader, MS21, which
is a von Hippel–Lindau (VHL)-recruiting proteolysis targeting chimera (PROTAC) based on …

Osteosarcoma is the most common malignant bone tumor, often occurring in children and
adolescents. The etiology of most patients is unclear, and the current conventional treatment …

Immunotherapy has revolutionized cancer treatment. Unfortunately, most tumor types do not
respond to immunotherapy due to a lack of immune infiltration or “cold” tumor …

Addressing the increasing incidences of cancer worldwide along with the multifaceted
problem of drug resistance via development of new anticancer agents has become an …

Aims: The circadian clock oscillates in a cell-autonomous manner with a period of∼ 24 h,
and the phase is regulated by various time cues such as light and temperature through …

Multiple myeloma grows by establishing multiple interactions with bone marrow cells. These
include expansion of myeloid-derived suppressor cells, which drive immunoevasion via …

Background: Protein kinase B (Akt) is a serine/threonine-protein kinase that drives the
diverse physiological process. Akt is a promising therapeutic target, which involves cancer …

Osteosarcoma is the most common malignant bone tumor, often occurring in children and
adolescents. The etiology of most patients is unclear, and the current conventional treatment …

TCP1, one of the subunits of molecular chaperone containing tailless complex polypeptide 1
(CCT)(CCT1), maybe play an essential role in cell proliferation and tumorigenesis. However …