Update on the pathogenesis of vitiligo

HZ Marchioro, CCS Castro, VM Fava… - Anais Brasileiros de …, 2022 - SciELO Brasil
Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic
components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the …

The humanistic burden of vitiligo: a systematic literature review of quality‐of‐life outcomes

M Picardo, RH Huggins, H Jones… - Journal of the …, 2022 - Wiley Online Library
Despite historical mischaracterization as a cosmetic condition, patients with the autoimmune
disorder vitiligo experience substantial quality‐of‐life (QoL) burden. This systematic …

[HTML][HTML] Two phase 3, randomized, controlled trials of ruxolitinib cream for vitiligo

D Rosmarin, T Passeron, AG Pandya… - … England Journal of …, 2022 - Mass Medical Soc
Background Vitiligo is a chronic autoimmune disease that causes skin depigmentation. A
cream formulation of ruxolitinib (an inhibitor of Janus kinase 1 and 2) resulted in …

Vitiligo prevalence and quality of life among adults in Europe, Japan and the USA

K Bibeau, AG Pandya, K Ezzedine… - Journal of the …, 2022 - Wiley Online Library
Background Vitiligo, an autoimmune disorder characterised by skin depigmentation, is
associated with reduced quality of life (QoL). Vitiligo may be under‐reported, in part because …

FDA approves Ruxolitinib (Opzelura) for Vitiligo Therapy: A breakthrough in the field of dermatology

A Sheikh, W Rafique, R Owais, F Malik… - Annals of medicine and …, 2022 - journals.lww.com
Abstract The Food and Drug Administration (FDA) has authorized Ruxolitinib (Opzelura), as
first at-home treatment for non-segmental vitiligo, an autoimmune condition that causes …

[HTML][HTML] Multimodal analyses of vitiligo skin idenitfy tissue characteristics of stable disease

J Shiu, L Zhang, G Lentsch, JL Flesher, S Jin… - JCI insight, 2022 - ncbi.nlm.nih.gov
Vitiligo is an autoimmune skin disease characterized by the destruction of melanocytes by
autoreactive CD8+ T cells. Melanocyte destruction in active vitiligo is mediated by CD8+ T …

[HTML][HTML] Vitiligo: a narrative review

RR Joge, PU Kathane, SH Joshi - Cureus, 2022 - ncbi.nlm.nih.gov
Vitiligo, a common depigmenting cutaneous condition, is thought to affect 0.5%-2% of the
world's population. During this condition, melanocytes are selectively lost, resulting in non …

Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors

S Faraj, EH Kemp… - Clinical and Experimental …, 2022 - academic.oup.com
Epidermal melanocyte loss in vitiligo, triggered by stresses ranging from trauma to emotional
stress, chemical exposure or metabolite imbalance, to the unknown, can stimulate oxidative …

Research progress on targeted antioxidant therapy and vitiligo

J Zhang, W Hu, P Wang, Y Ding… - … Medicine and Cellular …, 2022 - Wiley Online Library
Vitiligo is a common acquired depigmenting disease characterized by the loss of functional
melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results …

Effectiveness and safety of tofacitinib combined with narrowband ultraviolet B phototherapy for patients with refractory vitiligo in real‐world clinical practice

H Song, Z Hu, S Zhang, L Yang, Y Liu… - Dermatologic …, 2022 - Wiley Online Library
Vitiligo is a chronic treatment‐resistant autoimmune disorder characterized by circumscribed
depigmented maculae. This study was conducted to evaluate the efficacy and safety of …