Sustained release glaucoma therapies: Novel modalities for overcoming key treatment barriers associated with topical medications

A Belamkar, A Harris, R Zukerman, B Siesky… - Annals of …, 2022 - Taylor & Francis
Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness.
The disease has conventionally been characterized by an elevated intraocular pressure …

Primary glaucomas in adults: Epidemiology and public health‐A review

TF Reis, JS Paula, JM Furtado - Clinical & experimental …, 2022 - Wiley Online Library
Glaucoma is a mixed group of optic neuropathies that lead to irreversible visual field loss
and blindness if left untreated. It is estimated that 3.5% of the global population aged 40 to …

[HTML][HTML] Time trends, associations and prevalence of blindness and vision loss due to glaucoma: an analysis of observational data from the Global Burden of Disease …

Y Sun, A Chen, M Zou, Y Zhang, L Jin, Y Li, D Zheng… - BMJ open, 2022 - bmjopen.bmj.com
Objective To estimate global prevalence of blindness and vision loss caused by glaucoma,
and to evaluate the impact of socioeconomic factors on it. Design A population-based …

Hyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo …

AA Nemr, GM El-Mahrouk, HA Badie - Drug delivery, 2022 - Taylor & Francis
Agomelatine (AGO) is a dual-functional drug. It uses as an antidepressant when orally
administrated and antiglaucomic when topically applied to the eye. This study aimed to …

Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic

MF Cordeiro, D Hill, R Patel, P Corazza… - Progress in Retinal and …, 2022 - Elsevier
Abstract DARC (Detection of Apoptosing Retinal Cells) is a retinal imaging technology that
has been developed within the last 2 decades from basic laboratory science to Phase 2 …

Primary open angle glaucoma prevalence in Europe: a systematic review and meta-analysis

GG Afflitto, F Aiello, M Cesareo, C Nucci - Journal of Glaucoma, 2022 - journals.lww.com
Purpose: This study aimed to evaluate the prevalence of POAG in Europe. Methods: Two
authors independently conducted a systematic literature search on PubMed/MedLine, Web …

Glaucoma–risk factors and current challenges in the diagnosis of a leading cause of visual impairment

SSY Lee, DA Mackey - Maturitas, 2022 - Elsevier
Worldwide, glaucoma affects about 3% of the population over the age of 50 years and is a
leading cause of irreversible visual impairment among older people. Because glaucoma is …

Machine learning and deep learning techniques for optic disc and cup segmentation–a review

M Alawad, A Aljouie, S Alamri, M Alghamdi… - Clinical …, 2022 - Taylor & Francis
Background Globally, glaucoma is the second leading cause of blindness. Detecting
glaucoma in the early stages is essential to avoid disease complications, which lead to …

Transplanted human induced pluripotent stem cells-derived retinal ganglion cells embed within mouse retinas and are electrophysiologically functional

V Vrathasha, S Nikonov, BA Bell, J He, Y Bungatavula… - Iscience, 2022 - cell.com
Glaucoma is an optic neuropathy characterized by permanent visual field loss caused by the
death of retinal ganglion cells (RGCs) and it is the leading cause of irreversible blindness …

Diagnostic accuracy of artificial intelligence in glaucoma screening and clinical practice

AK Chaurasia, CJ Greatbatch, AW Hewitt - Journal of Glaucoma, 2022 - journals.lww.com
Purpose: Artificial intelligence (AI) has been shown as a diagnostic tool for glaucoma
detection through imaging modalities. However, these tools are yet to be deployed into …