Metastatic progression is the main cause of death in cancer patients, whereas the
underlying genomic mechanisms driving metastasis remain largely unknown. Here, we …

Immune checkpoint inhibitors (ICIs), including anti-programmed cell death-1/anti-
programmed cell death ligand-1 (anti-PD-1/PD-L1) therapy, have elicited impressive clinical …

KRAS mutation in colorectal cancer is associated with aggressive tumor behavior through
increased invasiveness and higher rates of lung metastases, but the biological mechanisms …

Background Despite curative hepatectomy, most colorectal liver metastasis (CRLM) patients
relapse locally within 2 years. Genomic predictors for hepatic recurrence are poorly …

Background KRAS mutation accounts for 30–50% of human colorectal cancer (CRC) cases.
Due to the scarcity of effective treatment options, KRAS mutant CRC is difficult to treat in the …

Simple Summary Cancer patients with synchronous lung metastasis (sLM) are recognized
as an entity with poor survival, and no consensus exists about which patients may benefit …

Background The lung is one of the most frequent distant metastasis sites in colorectal cancer
(CRC) patients; however, lung metastasis risk and prognostic factors have not been …

The lung is the most common extra‐abdominal metastasis site of colorectal cancer (CRC).
This study aimed to investigate the genetic variation of pulmonary metastases (PM) and …

Purpose: The metastatic site seems to represent a malignancy with a different biological
characteristic. Radiotherapy, as a successful, well-tolerated, cost-effective and time-efficient …

Das kolorektale Karzinom gehört zu den häufigsten Tumorentitäten und
Krebstodesursachen in Deutschland. Besonders beim Auftreten von Metastasen kommt es …