Prostate zones and cancer: lost in transition?
A Ali, A Du Feu, P Oliveira, A Choudhury… - Nature Reviews …, 2022 - nature.com
Localized prostate cancer shows great clinical, genetic and environmental heterogeneity;
however, prostate cancer treatment is currently guided solely by clinical staging, serum PSA …
however, prostate cancer treatment is currently guided solely by clinical staging, serum PSA …
[HTML][HTML] Understanding and targeting prostate cancer cell heterogeneity and plasticity
DG Tang - Seminars in cancer biology, 2022 - Elsevier
Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …
tumors in different patients manifest significant inter-patient heterogeneity with respect to …
[HTML][HTML] African-specific molecular taxonomy of prostate cancer
Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a
significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than …
significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than …
Molecular mechanisms underlying the development of neuroendocrine prostate cancer
Prostate cancer is the most common non-cutaneous cancer and the second leading cause
of cancer-associated deaths among men in the United States. Androgen deprivation therapy …
of cancer-associated deaths among men in the United States. Androgen deprivation therapy …
Expression and functions of long non-coding RNA NEAT1 and isoforms in breast cancer
NEAT1 is a highly abundant nuclear architectural long non-coding RNA. There are two
overlapping NEAT1 isoforms, NEAT1_1 and NEAT1_2, of which the latter is an essential …
overlapping NEAT1 isoforms, NEAT1_1 and NEAT1_2, of which the latter is an essential …
Starfish infers signatures of complex genomic rearrangements across human cancers
Complex genomic rearrangements (CGRs) are common in cancer and are known to form via
two aberrant cellular structures—micronuclei and chromatin bridges. However, which of …
two aberrant cellular structures—micronuclei and chromatin bridges. However, which of …
Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer toward androgen independence
In prostate cancer, androgen receptor (AR)–targeting agents are very effective in various
disease stages. However, therapy resistance inevitably occurs, and little is known about how …
disease stages. However, therapy resistance inevitably occurs, and little is known about how …
Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers
Background African ancestry is a significant risk factor for advanced prostate cancer (PCa).
Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the …
Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the …
From omics to multi-omics approaches for in-depth analysis of the molecular mechanisms of prostate cancer
E Nevedomskaya, B Haendler - International Journal of Molecular …, 2022 - mdpi.com
Cancer arises following alterations at different cellular levels, including genetic and
epigenetic modifications, transcription and translation dysregulation, as well as metabolic …
epigenetic modifications, transcription and translation dysregulation, as well as metabolic …
Experimental challenges to modeling prostate cancer heterogeneity
T del NJ Flores-Téllez, E Baena - Cancer Letters, 2022 - Elsevier
Tumor heterogeneity plays a key role in prostate cancer prognosis, therapy selection,
relapse, and acquisition of treatment resistance. Prostate cancer presents a heterogeneous …
relapse, and acquisition of treatment resistance. Prostate cancer presents a heterogeneous …