[HTML][HTML] Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke

Z Shen, M Xiang, C Chen, F Ding, Y Wang… - Biomedicine & …, 2022 - Elsevier
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy

A Movahedpour, O Vakili, M Khalifeh… - Cell biochemistry …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is one of the most concerning health issues in which the normal
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …

[HTML][HTML] More than a marker: potential pathogenic functions of MAP2

RA DeGiosio, MJ Grubisha, ML MacDonald… - Frontiers in molecular …, 2022 - frontiersin.org
Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

[HTML][HTML] Plants and phytochemicals potentials in tackling anxiety: a systematic review

N Phootha, N Yongparnichkul, Z Fang, RY Gan… - Phytomedicine Plus, 2022 - Elsevier
Background Anxiety is one of the psychiatric disorders that disturbs routine life including
moods and motivation. Excessive anxiety causes mental illnesses or anxiety disorders …

[HTML][HTML] Long-lasting BDNF signaling alterations in the amygdala of adolescent female rats exposed to the activity-based anorexia model

F Mottarlini, B Rizzi, G Targa, F Fumagalli… - Frontiers in Behavioral …, 2022 - frontiersin.org
Introduction: Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a
pathological fear of gaining weight, excessive physical exercise, and emotional instability …

MiR-153 downregulation alleviates PTSD-like behaviors and reduces cell apoptosis by upregulating the Sigma-1 receptor in the hippocampus of rats exposed to …

YL Chen, L Tong, Y Chen, CH Fu, JB Peng, LL Ji - Experimental neurology, 2022 - Elsevier
Posttraumatic stress disorder (PTSD) is a psychiatric disorder that may lead to a series of
changes in the central nervous system, including impaired synaptic plasticity, neuronal …

[HTML][HTML] Haloperidol-induced immediate early genes in striatopallidal neurons requires the converging action of cAMP/PKA/DARPP-32 and mTOR pathways

O Onimus, E Valjent, G Fisone… - International Journal of …, 2022 - mdpi.com
Antipsychotics share the common pharmacological feature of antagonizing the dopamine 2
receptor (D2R), which is abundant in the striatum and involved in both the therapeutic and …

[HTML][HTML] The evolving roles of alarin in physiological and disease conditions, and its future potential clinical implications

EC Abebe, MA Mengstie, MA Seid, T Malik… - Frontiers in …, 2022 - frontiersin.org
Alarin is a member of the galanin family of neuropeptides that is widely expressed in the
central nervous system and peripheral tissues in humans and rodents. It was initially …

[HTML][HTML] Regulatory effects and potential therapeutic implications of alarin in depression, and arguments on its receptor

EC Abebe, MA Mengstie, MA Seid… - Frontiers in Psychiatry, 2022 - frontiersin.org
Alarin is a pleiotropic peptide involved in a multitude of putative biological activities, notably,
it has a regulatory effect on depression-like behaviors. Although further elucidating research …

Melatonin prevented depressive-like behavior following cyclosporine A or interferon-α administration in mice

A Mesripour, M Aghamohseni - … University Journal of the Faculty of …, 2022 - dergipark.org.tr
Cyclosporine A (CYA) is prescribed to prevent graft rejection after transplantation. Interferon-
α (IFN-α), a natural cytokine, is prescribed for some types of malignancies, and hepatitis C …