Itch is a universally experienced sensation, and chronic itch can be as diabolically
debilitating as pain. Recent advances have not only identified the neuronal itch sensing …

Undermining new mediators involved in the development and progression of cardiovascular
diseases (CVDs) is vital for better disease management. Existing studies implicate a crucial …

Cellular senescence is implicated in a great number of diseases including cancer. Although
alterations in mitochondrial metabolism were reported as senescence drivers, the …

The histamine H1 receptor (H1R) has recently been implicated in mediating cell proliferation
and cancer progression; therefore, high-affinity H1R-selective fluorescent ligands are …

The molecular mechanism underlying the functional interaction between H1R and TRPV1
remains unclear. We show here that H1R directly binds to the carboxy-terminal region of …

Neurobiology has focused on understanding the functional and structural properties of the
brain as well as their ties to various toxicological and pathological processes. There has …

A major cause of cancer cell resistance to chemotherapeutics is the blocking of apoptosis
and induction of autophagy in the context of cell adaptation and survival. Therefore, new …

The histamine H1 receptor (H1R) is a G protein-coupled receptor (GPCR) and represents a
main target in the treatment of allergic reactions as well as inflammatory reactions and …

A new aptamer-adsorbed gold nanoparticles-based colorimetric method was developed for
sensitive detection of histamine, by taking advantage of the facts:(1) histamine can …

Due to the lack of an assessment approach, the image of in vivo nasal ciliary motion of
allergic rhinitis (AR) has never been captured and analyzed to date. Here, we have used an …