Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

Nuclear factor κB (NF-κB) is a ubiquitous regulator of the signalome and is indispensable for
various biological cell functions. NF-κB consists of five transcription factors that execute both …

Simple Summary Since its first description 35 years ago, the transcription factor NF-κB
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …

A subpopulation of cells in many cancers has stem cell traits, mediates metastasis, and
contributes to treatment resistance. These cells are considered as cancer stem cells (CSCs) …

Extensive research has been carried out to understand and elucidate the mechanisms of
paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular …

The immune system consists of various cells, organs, and processes that interact in a
sophisticated manner to defend against pathogens. Upon initial exposure to an invader …

The RNA binding protein ADAR3 is expressed exclusively in the brain and reported to have
elevated expression in tumors of patients suffering from glioblastoma compared to adjacent …

For many individuals, first exposure to alcohol occurs either prenatally due to maternal
drinking, or during adolescence, when alcohol consumption is most likely to be initiated …

Cancer is a leading cause of death worldwide. Casein kinase 2 (CK2) is commonly
dysregulated in cancer, impacting diverse molecular pathways. CK2 is a highly conserved …

Mouse hepatitis virus (MHV; m-β-CoV) serves as a useful model for studying the cellular
factors involved in neuroinflammation. To understand the role of matrix metalloproteinases …